{"product_id":"creb1-antibody-camp-response-element-binding-protein-1-bha17135744","title":"CREB1 Antibody \/ cAMP response element-binding protein 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eCREB1 Antibody \/ cAMP response element-binding protein 1 is a anti-CREB1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), ELISA with listed reactivity in Human, Monkey, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e CREB1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eCREB1 antibody detects cAMP response element-binding protein 1, a nuclear transcription factor that regulates gene expression in response to cAMP, calcium, and growth factor signaling. Encoded by the CREB1 gene on chromosome 2q34, this protein belongs to the CREB\/ATF family of transcription factors and is a master regulator of cellular proliferation, metabolism, and neuronal plasticity. CREB1 binds to the cAMP response element (CRE) in DNA, recruiting transcriptional coactivators such as CBP and p300 to stimulate RNA polymerase II-mediated transcription.\u003cbr\u003e\u003cbr\u003eStructurally, CREB1 contains an N-terminal kinase-inducible domain (KID) that undergoes phosphorylation at Ser133 upon activation by protein kinase A (PKA), calcium\/calmodulin-dependent protein kinases (CaMKs), or MAPK pathways. This modification enables high-affinity binding to CBP\/p300 and transcriptional activation of CRE-dependent genes involved in survival, learning, and glucose homeostasis. The C-terminal basic leucine zipper (bZIP) domain mediates DNA binding and dimerization with other CREB\/ATF proteins.\u003cbr\u003e\u003cbr\u003eThe CREB1 antibody is widely used in signal transduction, neuroscience, and endocrinology research to study gene expression control, synaptic plasticity, and second messenger signaling. Western blot analysis detects a 43 kilodalton band corresponding to CREB1, while immunofluorescence reveals nuclear localization with enrichment at transcriptionally active chromatin. This antibody is also effective for assessing phosphorylation-dependent activation in response to hormones, neurotransmitters, and stress stimuli.\u003cbr\u003e\u003cbr\u003eCREB1 activity is crucial for long-term memory formation, neuronal survival, and metabolic regulation. Dysregulation of CREB1 signaling contributes to neurological disorders, depression, diabetes, and tumorigenesis. In cancers, persistent CREB1 activation promotes proliferation and angiogenesis through induction of pro-survival genes such as BCL2 and VEGF. The CREB1 antibody provides a versatile reagent for dissecting transcriptional networks downstream of cAMP and growth factor pathways.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=CREB1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=CREB1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=CREB1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/CREB1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=CREB1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047303831917,"sku":"FY12842","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_69c0ee8c-fd8c-4d4a-9e42-9a0b0e6256c4.jpg?v=1782237044","url":"https:\/\/www.ebiohippo.com\/products\/creb1-antibody-camp-response-element-binding-protein-1-bha17135744","provider":"BioHippo","version":"1.0","type":"link"}