{"product_id":"creb3l2-antibody-cyclic-amp-responsive-element-binding-protein-3-like-protein-2-bha17136108","title":"CREB3L2 Antibody \/ Cyclic AMP-responsive element-binding protein 3-like protein 2","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eCREB3L2 Antibody \/ Cyclic AMP-responsive element-binding protein 3-like protein 2 is a anti-CREB3L2 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow cytometry (FACS) with listed reactivity in Human. Reported localization: ER, Nucleus.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e CREB3L2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, ICC\/IF, FACS\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eCREB3L2 antibody detects Cyclic AMP-responsive element-binding protein 3-like protein 2, a transcription factor that regulates endoplasmic reticulum (ER) stress response and secretory pathway gene expression. The UniProt recommended name is Cyclic AMP-responsive element-binding protein 3-like protein 2 (CREB3L2). This ER membrane-bound transcription factor modulates secretion, collagen synthesis, and stress adaptation through transcriptional control of Golgi and ER-resident proteins.\u003cbr\u003e\u003cbr\u003eFunctionally, CREB3L2 antibody identifies a 520-amino-acid protein anchored in the ER membrane via a C-terminal transmembrane domain. Upon ER stress or secretory stimulation, the N-terminal cytosolic fragment of CREB3L2 is cleaved and translocates to the nucleus, where it binds CRE-like sequences in target promoters to activate genes related to vesicle trafficking, extracellular matrix organization, and stress tolerance. CREB3L2 acts in concert with other bZIP transcription factors such as ATF6 and CREB3L1 to regulate protein folding and secretion.\u003cbr\u003e\u003cbr\u003eThe CREB3L2 gene is located on chromosome 7q33 and is highly expressed in secretory tissues such as cartilage, liver, and endocrine glands. It contributes to normal skeletal development and cellular adaptation to increased protein synthesis demands. CREB3L2 is also a critical determinant of collagen biosynthesis during chondrogenesis and wound repair.\u003cbr\u003e\u003cbr\u003ePathologically, translocations involving CREB3L2 and FUS lead to low-grade fibromyxoid sarcoma, resulting in constitutive transcriptional activation and altered differentiation. Aberrant CREB3L2 activity has also been implicated in metabolic and neurodegenerative disorders linked to ER stress. Research using CREB3L2 antibody supports studies in transcriptional control, ER stress, and tumor biology.\u003cbr\u003e\u003cbr\u003eCREB3L2 antibody is validated for western blotting, immunofluorescence, and immunohistochemistry to detect ER-associated transcription factors. \u003cbr\u003e\u003cbr\u003eStructurally, Cyclic AMP-responsive element-binding protein 3-like protein 2 features a basic leucine zipper (bZIP) DNA-binding domain, an ER luminal domain involved in sensing stress signals, and a transmembrane region that anchors it to the ER. This antibody aids in studying CREB3L2's role in secretory pathway regulation, collagen production, and tumorigenic gene fusion mechanisms.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=CREB3L2 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=CREB3L2 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=CREB3L2 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/CREB3L2 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=CREB3L2+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047318282605,"sku":"FY13206","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_467f5595-8e3f-4f28-a8c8-4182cd934c3f.jpg?v=1782237088","url":"https:\/\/www.ebiohippo.com\/products\/creb3l2-antibody-cyclic-amp-responsive-element-binding-protein-3-like-protein-2-bha17136108","provider":"BioHippo","version":"1.0","type":"link"}