{"product_id":"crp-antibody-c-reactive-protein-bha17135636","title":"CRP Antibody \/ C Reactive Protein","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eCRP Antibody \/ C Reactive Protein is a anti-CRP Rabbit antibody Recombinant Rabbit Monoclonal clone 32C44 supplied in Liquid format. Recommended for workflows such as Western blot (WB) with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e CRP\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 32C44, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eCRP antibody detects C reactive protein, a major acute phase protein encoded by the CRP gene. CRP is also known as pentraxin related protein and pentraxin 1. It belongs to the pentraxin family of pattern recognition molecules and circulates in serum as a pentameric protein. CRP binds to phosphocholine on microbial surfaces and damaged host cells, activating the classical complement pathway and enhancing phagocytosis. Its levels rise dramatically during infection, inflammation, and tissue injury, making CRP one of the most widely used clinical biomarkers of inflammation.\u003cbr\u003e\u003cbr\u003eCRP antibody is widely applied in immunology, cardiology, and translational medicine. In clinical diagnostics, CRP is measured to monitor infection, sepsis, and chronic inflammatory diseases. High sensitivity CRP assays provide prognostic information in cardiovascular disease, linking elevated CRP levels to increased risk of myocardial infarction and stroke. By detecting CRP, researchers and clinicians can evaluate systemic inflammatory responses and disease severity.\u003cbr\u003e\u003cbr\u003e ELISA with CRP antibody allows quantitative measurement of serum concentrations. Immunohistochemistry detects CRP deposition in tissues, while western blotting confirms protein expression and isoform detection. These methods support research into CRP biology and clinical monitoring of inflammatory states.\u003cbr\u003e\u003cbr\u003eBeyond its diagnostic utility, CRP plays roles in innate immunity by bridging recognition of pathogens with activation of complement and Fc receptor mediated pathways. It contributes to clearance of apoptotic cells and immune complexes. Dysregulation of CRP expression or function is implicated in autoimmunity and chronic inflammatory disease. By applying CRP antibody, scientists can investigate how this acute phase protein contributes to host defense and pathology.\u003cbr\u003e\u003cbr\u003eCRP antibody from\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=CRP - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=CRP - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=CRP - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/CRP - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=CRP+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047298523501,"sku":"FY12733","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_302d1bca-6023-4991-b8c5-45daf2c49e00.jpg?v=1772019335","url":"https:\/\/www.ebiohippo.com\/products\/crp-antibody-c-reactive-protein-bha17135636","provider":"BioHippo","version":"1.0","type":"link"}