{"product_id":"csde1-antibody-cold-shock-domain-containing-e1-bha17135862","title":"CSDE1 Antibody \/ Cold shock domain-containing E1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eCSDE1 Antibody \/ Cold shock domain-containing E1 is a anti-CSDE1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as ELISA, Flow cytometry (FACS), Western blot (WB) with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e CSDE1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e ELISA, FACS, WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eCSDE1 antibody detects Cold shock domain-containing E1, an RNA-binding protein that regulates mRNA stability, translation, and stress response. The UniProt recommended name is Cold shock domain-containing protein E1 (CSDE1), also known as UNR (upstream of N-ras). This multifunctional RNA-binding factor modulates gene expression at post-transcriptional levels and participates in stress granule dynamics, cell differentiation, and viral replication control.\u003cbr\u003e\u003cbr\u003eFunctionally, CSDE1 antibody recognizes a 794-amino-acid protein containing five cold-shock domains (CSDs) that mediate single-stranded RNA binding. CSDE1 interacts with translation initiation factors and RNA helicases to regulate both cap-dependent and internal ribosome entry site (IRES)-mediated translation. It influences the expression of key regulatory proteins involved in cell growth, apoptosis, and stress adaptation. Through its control of mRNA turnover and translation, CSDE1 coordinates cellular response to nutrient deprivation, hypoxia, and oxidative stress.\u003cbr\u003e\u003cbr\u003eThe CSDE1 gene is located on chromosome 1p13.2 and is highly expressed in neurons, germ cells, and proliferating tissues. It associates with messenger ribonucleoprotein (mRNP) complexes and localizes to cytoplasmic granules under stress conditions. CSDE1 regulates the translation of c-Fos, Apaf1, and XIAP mRNAs, thereby balancing apoptosis and survival pathways. It also contributes to differentiation processes in embryonic stem cells and neuronal precursors through translational control mechanisms.\u003cbr\u003e\u003cbr\u003eIn virology, CSDE1 plays a dual role as a host factor that both supports and restricts viral replication, depending on the virus type. For example, it facilitates poliovirus IRES-mediated translation but limits the replication of certain RNA viruses by sequestering viral transcripts. In cancer, dysregulated CSDE1 expression promotes oncogenic translation programs, including MYC and PTEN pathway regulation. Its overexpression correlates with increased metastasis and poor prognosis in melanoma and prostate cancer.\u003cbr\u003e\u003cbr\u003eCSDE1 antibody is used for immunoblotting, immunocytochemistry, and RNA immunoprecipitation to study RNA-protein interactions, translation control, and stress response mechanisms. In neuronal models, CSDE1 localization shifts dynamically between cytoplasm and stress granules, reflecting its regulatory versatility. Structural analyses reveal that each CSD contributes distinct RNA-binding affinities, allowing CSDE1 to recognize a broad spectrum of RNA targets and adapt to various signaling environments.\u003cbr\u003e\u003cbr\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=CSDE1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=CSDE1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=CSDE1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/CSDE1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=CSDE1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047307108717,"sku":"FY12960","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_e0339c80-6b08-42f8-9ef3-a083b5bb2166.jpg?v=1782237061","url":"https:\/\/www.ebiohippo.com\/products\/csde1-antibody-cold-shock-domain-containing-e1-bha17135862","provider":"BioHippo","version":"1.0","type":"link"}