{"product_id":"ctnnbl1-antibody-catenin-beta-like-1-bha17135223","title":"CTNNBL1 Antibody \/ Catenin beta like 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eCTNNBL1 Antibody \/ Catenin beta like 1 is a anti-CTNNBL1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Flow cytometry (FACS), ELISA with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e CTNNBL1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eCTNNBL1 antibody is used to study Catenin beta like 1, a nuclear protein that plays critical roles in RNA splicing, nuclear import, and regulation of the cell cycle. Unlike classical catenins that stabilize cadherin complexes at the cell membrane, Catenin beta like 1 is localized to the nucleus and interacts with core spliceosome proteins to ensure fidelity of pre-mRNA processing. This specialization makes CTNNBL1 a distinct member of the catenin-related family and a protein of increasing interest to molecular biologists.\u003cbr\u003e\u003cbr\u003eCatenin beta like 1 contains armadillo (ARM) repeat domains that are structurally related to those in beta-catenin, but its function diverges toward nuclear events. Through these domains, CTNNBL1 associates with CDC5L, PRPF19, and additional splicing regulators, anchoring them within the spliceosomal complex. These interactions preserve accurate transcript maturation, prevent errors in gene expression, and safeguard the cell against the downstream consequences of mis-splicing. Because abnormal splicing can drive both oncogenesis and immune dysfunction, researchers frequently use CTNNBL1 antibody to map spliceosome activity and evaluate how this protein stabilizes nuclear machinery.\u003cbr\u003e\u003cbr\u003eRecent studies have shown that Catenin beta like 1 is not limited to splicing but also functions in nuclear import pathways. CTNNBL1 assists in shuttling proteins that contain nuclear localization signals, ensuring that transcription factors and regulatory proteins reach the nucleus where they execute their functions. This process is fundamental for cell cycle regulation, DNA repair, and stress responses. When CTNNBL1 is disrupted, cells display impaired nuclear transport, altered gene expression, and reduced viability, underscoring its essential nature. With CTNNBL1 antibody, scientists can visualize these processes in detail using immunofluorescence, western blotting, and immunoprecipitation approaches.\u003cbr\u003e\u003cbr\u003eCancer biology has highlighted the importance of Catenin beta like 1. Abnormal expression of CTNNBL1 has been detected in colorectal cancer, breast cancer, and hematological malignancies, linking its function to tumor progression. Genetic polymorphisms in the CTNNBL1 gene have also been associated with autoimmune disease susceptibility and even with responses to viral infections. Researchers can therefore employ CTNNBL1 antibody to investigate how this nuclear factor contributes to disease risk, therapeutic response, and the molecular shifts that occur in malignancy. These insights are critical for understanding how dysregulated splicing and nuclear transport alter cell fate in pathological states.\u003cbr\u003e\u003cbr\u003eThe CTNNBL1 antibody offered by \u003cbr\u003e\u003cbr\u003eBeyond cancer and immunity, CTNNBL1 has relevance in developmental biology. Proper splicing and nuclear transport are fundamental for embryogenesis, and disruption of CTNNBL1 can impair tissue growth and differentiation. Neurobiology research has also turned attention to CTNNBL1, as RNA processing errors are linked to neurodegenerative conditions such as amyotrophic lateral sclerosis and spinal muscular atrophy. By applying CTNNBL1 antibody in these areas, investigators can track how RNA maturation and nuclear protein import influence neural survival and function.\u003cbr\u003e\u003cbr\u003eAs more laboratories study the consequences of RNA dysregulation, CTNNBL1 antibody has become an indispensable reagent for connecting nuclear mechanics to cellular phenotypes. Its applications in cancer, autoimmunity, virology, and neurodegeneration research reflect the broad significance of Catenin beta like 1 in human biology. The antibody provided by\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=CTNNBL1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=CTNNBL1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=CTNNBL1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/CTNNBL1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=CTNNBL1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047284629869,"sku":"FY12320","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_34ec685f-1f95-4593-a28b-6e99bc49719e.jpg?v=1782236989","url":"https:\/\/www.ebiohippo.com\/products\/ctnnbl1-antibody-catenin-beta-like-1-bha17135223","provider":"BioHippo","version":"1.0","type":"link"}