{"product_id":"ctrc-antibody-chymotrypsin-c-bha17135780","title":"CTRC Antibody \/ Chymotrypsin C","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eCTRC Antibody \/ Chymotrypsin C is a anti-CTRC Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC) with listed reactivity in Human, Rat. Reported localization: Cytoplasm, extracellular.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e CTRC\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eCTRC antibody detects Chymotrypsin C, a digestive serine protease that regulates pancreatic enzyme activation and degradation. Encoded by the CTRC gene on chromosome 1p36.21, this enzyme is secreted by pancreatic acinar cells and plays a dual role in digestive proteolysis and zymogen activation control. CTRC contributes to the post-translational activation of trypsinogen and other pancreatic proteases while simultaneously degrading prematurely activated trypsin to prevent autodigestion and pancreatitis.\u003cbr\u003e\u003cbr\u003eStructurally, Chymotrypsin C is synthesized as an inactive zymogen (chymotrypsinogen C) and activated by proteolytic cleavage in the small intestine. The mature enzyme is approximately 29 kilodaltons and contains a catalytic triad (His, Asp, Ser) characteristic of serine proteases. CTRC exhibits substrate specificity distinct from other chymotrypsins, favoring cleavage after bulky hydrophobic residues and acting on peptide bonds within pancreatic proenzymes and regulatory proteins.\u003cbr\u003e\u003cbr\u003eThe CTRC antibody is widely used in digestive biology, enzymology, and pancreatic disease research to study protease regulation, secretion, and zymogen activation. Western blot analysis detects a 29 kilodalton band corresponding to the active enzyme, while immunohistochemistry reveals cytoplasmic staining in pancreatic acinar cells. This antibody supports research on digestive enzyme control, pancreatitis pathogenesis, and exocrine pancreas physiology.\u003cbr\u003e\u003cbr\u003eMutations in CTRC are associated with hereditary chronic pancreatitis and idiopathic pancreatic inflammation, where loss of enzyme function impairs trypsin degradation, leading to excessive intrapancreatic activation. CTRC variants can also affect digestive efficiency and susceptibility to pancreatic stress. Beyond digestion, CTRC influences the proteolytic processing of hormones and growth factors, expanding its role in systemic protease regulation. The CTRC antibody provides a reliable tool for studying enzyme expression, activity regulation, and genetic variants linked to pancreatic disease.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=CTRC - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=CTRC - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=CTRC - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/CTRC - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=CTRC+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047304683885,"sku":"FY12878","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_49862e59-1506-4f8e-8263-849a229a2552.jpg?v=1782237062","url":"https:\/\/www.ebiohippo.com\/products\/ctrc-antibody-chymotrypsin-c-bha17135780","provider":"BioHippo","version":"1.0","type":"link"}