{"product_id":"cxcl13-antibody-c-x-c-motif-chemokine-13-bca1-bha17135810","title":"CXCL13 Antibody \/ C-X-C motif chemokine 13 \/ BCA1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eCXCL13 Antibody \/ C-X-C motif chemokine 13 \/ BCA1 is a anti-CXCL13 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Flow cytometry (FACS), Immunohistochemistry (IHC), Western blot (WB) with listed reactivity in Human. Reported localization: Cytoplasmic, secreted.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e CXCL13\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e FACS, IHC, WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eCXCL13 antibody detects C-X-C motif chemokine 13 (also known as B cell-attracting chemokine 1 or BCA1), a small secreted chemokine that directs B cell migration and lymphoid tissue organization. Encoded by the CXCL13 gene on chromosome 4q21.1, this protein belongs to the CXC chemokine family and binds to the receptor CXCR5 on B cells and follicular helper T cells, guiding them into lymphoid follicles during immune responses. CXCL13 plays a pivotal role in germinal center formation and antibody-mediated immunity.\u003cbr\u003e\u003cbr\u003eStructurally, CXCL13 is a 109-amino-acid secreted protein of approximately 12 kilodaltons that adopts a characteristic chemokine fold stabilized by disulfide bonds. It is expressed by follicular dendritic cells, stromal cells, and certain epithelial and endothelial cells in lymphoid tissues. Upon secretion, CXCL13 establishes chemotactic gradients that attract CXCR5-positive lymphocytes to B cell zones within lymph nodes, spleen, and tertiary lymphoid structures.\u003cbr\u003e\u003cbr\u003eThe CXCL13 antibody is widely used in immunology, oncology, and infectious disease research to study chemokine signaling, germinal center formation, and immune cell trafficking. Western blot analysis detects a 12 kilodalton band corresponding to CXCL13, while immunohistochemistry reveals extracellular and stromal staining patterns within lymphoid tissues. This antibody supports quantitative and localization studies of B cell chemotactic signaling and lymphoid organogenesis.\u003cbr\u003e\u003cbr\u003eFunctionally, CXCL13 orchestrates the spatial organization of adaptive immune responses by regulating migration of B cells and T follicular helper cells. Overexpression of CXCL13 is observed in autoimmune diseases such as rheumatoid arthritis, Sjogren's syndrome, and systemic lupus erythematosus, where ectopic lymphoid structures form in inflamed tissues. It also serves as a biomarker for certain cancers and viral infections, reflecting local immune activation. The CXCL13 antibody provides a sensitive and specific reagent for assessing chemokine expression in tissue sections and culture systems.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=CXCL13 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=CXCL13 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=CXCL13 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/CXCL13 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=CXCL13+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047306092909,"sku":"FY12908","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_aaf766d5-ca4f-4bbe-ae8d-b31f6d1c5922.jpg?v=1782237053","url":"https:\/\/www.ebiohippo.com\/products\/cxcl13-antibody-c-x-c-motif-chemokine-13-bca1-bha17135810","provider":"BioHippo","version":"1.0","type":"link"}