{"product_id":"cxcr5-antibody-c-x-c-chemokine-receptor-type-5-bha17136317","title":"CXCR5 Antibody | C-X-C chemokine receptor type 5","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eCXCR5 Antibody | C-X-C chemokine receptor type 5 is a anti-CXCR5 Rabbit antibody Recombinant Rabbit Monoclonal clone 20C58 supplied in Purified format. Recommended for workflows such as Western blot (WB), IHC-P with listed reactivity in Human, Mouse, Rat. Reported localization: Cytoplasm.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e CXCR5\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 20C58, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC-P\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eC-X-C chemokine receptor type 5 (CXCR5) is a G protein-coupled receptor primarily expressed on B cells and certain subsets of T cells. It binds the chemokine CXCL13, guiding lymphocyte migration to B cell follicles within secondary lymphoid organs. CXCR5 plays a crucial role in lymphoid tissue organization and immune surveillance.    \u003cp\u003eCXCR5 is essential for germinal center formation and effective humoral immune responses. Altered expression or function of CXCR5 has been associated with autoimmune diseases, immunodeficiencies, and certain cancers, making it an important focus in immunology and oncology research. \u003c\/p\u003e\n\u003cp\u003eUsing a high-quality CXCR5 antibody enables sensitive detection in applications such as flow cytometry, immunohistochemistry, and western blot. A CXCR5 antibody from\u003c\/p\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=CXCR5 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=CXCR5 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=CXCR5 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/CXCR5 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=CXCR5+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047324803437,"sku":"RQ8898","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_a5a9b675-ca48-49eb-9f64-0e0a7f0a9fe2.jpg?v=1772019443","url":"https:\/\/www.ebiohippo.com\/products\/cxcr5-antibody-c-x-c-chemokine-receptor-type-5-bha17136317","provider":"BioHippo","version":"1.0","type":"link"}