{"product_id":"cyclin-dependent-kinase-14-antibody-cdk14-pftaire-1-bha17103399","title":"Cyclin-dependent kinase 14 Antibody \/ CDK14 \/ PFTAIRE-1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e \u003cp\u003eCyclin-dependent kinase 14 antibody supplied as a purified reagent for WB, IHC-P in Human, Mouse samples. This product is a polyclonal (rabbit origin) antibody (host: Rabbit; isotype: Rabbit Ig) intended for research use only. The target is commonly annotated with nuclear, cytoplasmic localization context, which may inform staining patterns.\u003c\/p\u003e \u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e \u003cul\u003e   \u003cli\u003e\n\u003cstrong\u003eAntibody identity:\u003c\/strong\u003e Polyclonal (rabbit origin); host Rabbit; isotype Rabbit Ig.\u003c\/li\u003e   \u003cli\u003e\n\u003cstrong\u003eFormat and purification:\u003c\/strong\u003e format: Purified; purity: Antigen affinity purified.\u003c\/li\u003e   \u003cli\u003e\n\u003cstrong\u003eSpecies reactivity (reported):\u003c\/strong\u003e Human, Mouse.\u003c\/li\u003e   \u003cli\u003e\n\u003cstrong\u003eApplications (listed):\u003c\/strong\u003e WB, IHC-P.\u003c\/li\u003e   \u003cli\u003e\n\u003cstrong\u003eImmunogen \/ epitope context:\u003c\/strong\u003e A portion of amino acids 1-30 from the human protein was used as the immunogen for the Cyclin-dependent kinase 14 antibody..\u003c\/li\u003e   \u003cli\u003e\n\u003cstrong\u003eLocalization:\u003c\/strong\u003e Nuclear, cytoplasmic (annotation-level guidance; cell state and isoforms can shift patterns).\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eThese attributes help you align the antibody with the biological question (target state, sample type, and readout) while keeping interpretation grounded in appropriate controls.\u003c\/p\u003e \u003ch2\u003eBiological background\u003c\/h2\u003e \u003cp\u003eCyclin-dependent kinase 14 is the intended antigen for this primary antibody. Reported biological context includes: Cyclin-dependent kinase 14, a member of the CDC2\/CDKX subfamily of Ser\/Thr protein kinases, may play a role in meiosis as well as in neuron differentiation and\/or function It is highly expressed in brain, pancreas, kidney, heart, testis and ovary, and also detected at lower levels in other tissues except in spleen and thymus where expression is minimal. Subcellular localization information (Nuclear, cytoplasmic) can be useful when interpreting IF\/ICC patterns and selecting compartment-enriched lysates for WB.\u003c\/p\u003e \u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e \u003cul\u003e   \u003cli\u003eSignal-flow and turnover studies: researchers pair immunodetection with perturbations that modulate enzymatic activity or proteostasis to understand regulation, stability, and feedback.\u003c\/li\u003e   \u003cli\u003eSpatial and single-cell approaches: imaging-based and cytometry workflows increasingly quantify heterogeneity and relocalization rather than only bulk abundance.\u003c\/li\u003e   \u003cli\u003eInteraction-centric biology: IP-based enrichment and proteomics are widely used to define complexes, binding partners, and context-specific interactomes.\u003c\/li\u003e \u003c\/ul\u003e \u003ch2\u003eCommon research applications\u003c\/h2\u003e \u003cul\u003e   \u003cli\u003eWestern blot (WB): compare relative abundance\/isoform patterns across conditions and sample types; band shifts may reflect processing or post-translational modification.\u003c\/li\u003e   \u003cli\u003eIHC-P: commonly used to measure relative target levels or localization changes in the context of the experimental question.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eAcross these readouts, differences in signal intensity, localization, or complex enrichment are typically interpreted alongside sample-matched controls and independent evidence to distinguish regulation from technical variation.\u003c\/p\u003e \u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e \u003cul\u003e   \u003cli\u003eIsoforms, cleavage products, or post-translational modifications can alter apparent molecular weight and subcellular distribution; interpret bands and staining patterns in the context of expected biology and sample preparation.\u003c\/li\u003e   \u003cli\u003eSpecies differences and epitope conservation may affect binding; use matched positive controls and orthogonal evidence when comparing across organisms.\u003c\/li\u003e   \u003cli\u003eControl concepts: include appropriate isotype and secondary-only controls (for imaging), and consider genetic perturbations (knockout\/knockdown\/overexpression) or independent antibodies targeting distinct epitopes to strengthen conclusions.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eEpitope context is defined by the immunogen description; when available, align this with known domains, PTM sites, or family homology to anticipate potential cross-reactivity patterns. As a polyclonal antibody, recognition spans multiple epitopes, which can improve detection across conformations but may broaden background depending on sample context.\u003c\/p\u003e \u003c!-- Sources (internal): - UniProtKB entry (O94921) — UniProt Consortium — https:\/\/www.uniprot.org\/uniprotkb\/O94921\/entry - NCBI Gene search (Cyclin-dependent kinase 14) — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=Cyclin-dependent+kinase+14 - Ensembl search (Cyclin-dependent kinase 14) — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=Cyclin-dependent+kinase+14 - PubMed search (Cyclin-dependent kinase 14) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Cyclin-dependent+kinase+14 - Reactome pathway search (Cyclin-dependent kinase 14) — Reactome — https:\/\/reactome.org\/content\/query?q=Cyclin-dependent+kinase+14 --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"In 1X PBS, pH 7.4, with 0.09% sodium azide \/ 0.08 ml","offer_id":53043238273389,"sku":"F54938-0.08ML","price":205.0,"currency_code":"USD","in_stock":true},{"title":"In 1X PBS, pH 7.4, with 0.09% sodium azide \/ 0.4 ml","offer_id":53043658162541,"sku":"F54938-0.4ML","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_ffd533e7-b1bb-4154-bed6-14d7543e7283.jpg?v=1771934331","url":"https:\/\/www.ebiohippo.com\/products\/cyclin-dependent-kinase-14-antibody-cdk14-pftaire-1-bha17103399","provider":"BioHippo","version":"1.0","type":"link"}