{"product_id":"cyp1b1-antibody-cytochrome-p450-1b1-bha17135853","title":"CYP1B1 Antibody \/ Cytochrome P450 1B1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eCYP1B1 Antibody \/ Cytochrome P450 1B1 is a anti-CYP1B1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e CYP1B1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eCYP1B1 antibody detects Cytochrome P450 1B1, a member of the cytochrome P450 superfamily of monooxygenases involved in xenobiotic metabolism, steroid synthesis, and carcinogen activation. The UniProt recommended name is Cytochrome P450 1B1 (CYP1B1). This enzyme catalyzes oxidative reactions that introduce oxygen atoms into lipophilic substrates, enhancing their solubility and excretion. It is localized in the endoplasmic reticulum and expressed in various tissues, including liver, lung, eye, and reproductive organs.\u003cbr\u003e\u003cbr\u003eFunctionally, CYP1B1 antibody identifies a 543-amino-acid heme-binding enzyme that catalyzes hydroxylation reactions using NADPH and cytochrome P450 reductase as cofactors. CYP1B1 metabolizes diverse substrates such as estrogens, fatty acids, retinoids, and xenobiotics including polycyclic aromatic hydrocarbons (PAHs). Its activity contributes to detoxification as well as bioactivation of environmental procarcinogens. The enzyme's ability to generate reactive intermediates links it to oxidative DNA damage and tumor initiation.\u003cbr\u003e\u003cbr\u003eThe CYP1B1 gene is located on chromosome 2p22.2 and contains multiple polymorphisms influencing enzyme activity and disease susceptibility. Mutations in CYP1B1 are a primary cause of primary congenital glaucoma (PCG), due to impaired metabolism of signaling molecules essential for ocular development. In adults, altered CYP1B1 expression is associated with various cancers, including breast, ovarian, and prostate carcinoma, where it modulates estrogen metabolism and tumor progression.\u003cbr\u003e\u003cbr\u003eCYP1B1 antibody is used to study xenobiotic metabolism, hormonal regulation, and oxidative stress responses. The enzyme catalyzes 4-hydroxylation of estradiol, producing metabolites that influence estrogen receptor signaling and carcinogenesis. CYP1B1 expression is inducible by environmental toxins such as dioxins and polyaromatic compounds through activation of the aryl hydrocarbon receptor (AhR) pathway. As a result, CYP1B1 serves as a biomarker of chemical exposure and detoxification capacity.\u003cbr\u003e\u003cbr\u003eStructurally, CYP1B1 contains a conserved heme-binding domain (Cys-Gly-Gly-His motif) and a hydrophobic membrane anchor. It functions as a monooxygenase by inserting one atom of molecular oxygen into the substrate while reducing the other to water. Regulation occurs via transcriptional control, particularly through AhR-mediated gene induction. Post-translational modifications and redox conditions further modulate its catalytic activity.\u003cbr\u003e\u003cbr\u003eA CYP1B1 antibody is suitable for immunoblotting, immunohistochemistry, and enzyme activity assays to investigate tissue-specific expression and regulation. Its detection assists in understanding how xenobiotic metabolism impacts oxidative balance, endocrine signaling, and cancer susceptibility.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=CYP1B1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=CYP1B1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=CYP1B1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/CYP1B1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=CYP1B1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047307370861,"sku":"FY12951","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_d1d2272b-0db8-4c25-a441-f531b318d69f.jpg?v=1782237062","url":"https:\/\/www.ebiohippo.com\/products\/cyp1b1-antibody-cytochrome-p450-1b1-bha17135853","provider":"BioHippo","version":"1.0","type":"link"}