{"product_id":"cyp26b1-antibody-cytochrome-p450-26b1-bha17136022","title":"CYP26B1 Antibody \/ Cytochrome P450 26B1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eCYP26B1 Antibody \/ Cytochrome P450 26B1 is a anti-CYP26B1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat. Reported localization: Cytoplasm (ER).\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e CYP26B1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, ICC\/IF, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eCYP26B1 antibody detects Cytochrome P450 26B1, a retinoic acid-metabolizing enzyme that controls tissue-specific retinoid signaling. The UniProt recommended name is Cytochrome P450 26B1 (CYP26B1). This enzyme belongs to the cytochrome P450 superfamily and catalyzes the hydroxylation and inactivation of all-trans-retinoic acid, maintaining its spatial and temporal concentration during development.\u003cbr\u003e\u003cbr\u003eFunctionally, CYP26B1 antibody identifies a 512-amino-acid endoplasmic reticulum membrane protein containing a heme-binding domain essential for oxidative metabolism. CYP26B1 converts retinoic acid into hydroxylated metabolites such as 4-hydroxy-retinoic acid and 18-hydroxy-retinoic acid. This reaction ensures proper morphogen gradients required for organ patterning, skeletal formation, and germ cell development.\u003cbr\u003e\u003cbr\u003eThe CYP26B1 gene is located on chromosome 2p13.2 and is expressed in multiple tissues, including brain, liver, gonads, and embryonic structures. During embryogenesis, CYP26B1 expression establishes regional retinoic acid boundaries, preventing inappropriate activation of retinoic acid-responsive genes. In adults, CYP26B1 regulates tissue regeneration and detoxification of retinoid compounds.\u003cbr\u003e\u003cbr\u003ePathologically, mutations or altered CYP26B1 expression are associated with developmental defects such as craniofacial malformations, skeletal abnormalities, and infertility. Overexpression has also been linked to tumor progression via retinoid resistance. Research using CYP26B1 antibody supports studies in developmental biology, metabolism, and retinoid pharmacology.\u003cbr\u003e\u003cbr\u003eCYP26B1 antibody is validated for western blotting, immunohistochemistry, and enzyme assays to detect cytochrome P450 enzymes involved in retinoid metabolism. \u003cbr\u003e\u003cbr\u003eStructurally, Cytochrome P450 26B1 features conserved P450 motifs, including the heme-binding cysteine loop and oxygen activation domains. This antibody aids studies on CYP26B1's role in retinoid turnover, tissue patterning, and disease development.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=CYP26B1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=CYP26B1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=CYP26B1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/CYP26B1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=CYP26B1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047313105261,"sku":"FY13120","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_b94f61b2-82b7-4054-afaf-b6536a15da31.jpg?v=1782237092","url":"https:\/\/www.ebiohippo.com\/products\/cyp26b1-antibody-cytochrome-p450-26b1-bha17136022","provider":"BioHippo","version":"1.0","type":"link"}