{"product_id":"cyp2w1-antibody-cytochrome-p450-2w1-bha17136154","title":"CYP2W1 Antibody \/ Cytochrome P450 2W1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eCYP2W1 Antibody \/ Cytochrome P450 2W1 is a anti-CYP2W1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC) with listed reactivity in Human. Reported localization: ER, cell membrane.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e CYP2W1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eCYP2W1 antibody detects Cytochrome P450 2W1, a monooxygenase enzyme involved in xenobiotic metabolism and drug activation. The UniProt recommended name is Cytochrome P450 2W1 (CYP2W1). This enzyme belongs to the cytochrome P450 superfamily, a large group of heme-thiolate proteins that catalyze oxidative reactions essential for detoxification and bioactivation of endogenous and exogenous compounds.\u003cbr\u003e\u003cbr\u003eFunctionally, CYP2W1 antibody identifies a 490-amino-acid membrane-bound enzyme localized to the endoplasmic reticulum. CYP2W1 utilizes NADPH-cytochrome P450 reductase as an electron donor to catalyze monooxygenation of various substrates including fatty acids, indole derivatives, and xenobiotics. Although minimally expressed in adult tissues, CYP2W1 is highly active in embryonic development and selectively re-expressed in certain cancers, where it contributes to prodrug metabolism and tumor-specific bioactivation.\u003cbr\u003e\u003cbr\u003eThe CYP2W1 gene is located on chromosome 7q22.3 and is expressed predominantly in colon, adrenal gland, and fetal tissues. Expression is regulated by epigenetic mechanisms such as DNA methylation and histone modification, restricting CYP2W1 activity to specific developmental and pathological contexts.\u003cbr\u003e\u003cbr\u003ePathologically, CYP2W1 has gained attention as a tumor-specific biomarker and therapeutic target due to its selective expression in colon, adrenal, and lung cancers. It catalyzes activation of several anticancer prodrugs, providing potential for targeted therapy. Conversely, its aberrant activity may contribute to tumor progression by metabolizing endogenous substrates into bioactive lipids. Research using CYP2W1 antibody supports studies in pharmacology, oncology, and drug metabolism.\u003cbr\u003e\u003cbr\u003eCYP2W1 antibody is validated for western blotting, immunohistochemistry, and ELISA to detect cytochrome P450 enzymes. \u003cbr\u003e\u003cbr\u003eStructurally, Cytochrome P450 2W1 contains a conserved P450 fold with heme-binding motifs (FGxGPR and Cys-pocket) and a hydrophobic N-terminal region for membrane anchoring. The active site accommodates small aromatic and aliphatic compounds, enabling broad substrate specificity. This antibody allows investigation of CYP2W1's function in tissue-specific metabolism and its emerging role in cancer therapeutics.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=CYP2W1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=CYP2W1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=CYP2W1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/CYP2W1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=CYP2W1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047319953773,"sku":"FY13252","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_5e719b53-a961-479b-b010-93ee3603495d.jpg?v=1782237086","url":"https:\/\/www.ebiohippo.com\/products\/cyp2w1-antibody-cytochrome-p450-2w1-bha17136154","provider":"BioHippo","version":"1.0","type":"link"}