{"product_id":"cytochalasin-e-bhb21300105","title":"Cytochalasin E","description":"\u003ch3\u003eProduct details\u003c\/h3\u003e \u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eChemical name:\u003c\/strong\u003e 21,23-Dioxa[13]cytochalasa-13,19-diene-1,17,22- trione,6,7-epoxy-18-hydroxy-16,18-dimethyl-10-phenyl-,(7S,13E,16S,18R,19E)-.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS number:\u003c\/strong\u003e 36011-19-5\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular formula:\u003c\/strong\u003e C28H33NO7.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;99%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConcentration:\u003c\/strong\u003e 0.1-10 µM.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized powder.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSolubility:\u003c\/strong\u003e Water, DMSO, ethanol, methanol, acetone. Centrifuge all product preparations before use (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReconstitution:\u003c\/strong\u003e Water, DMSO, ethanol, methanol, acetone. Centrifuge all product preparations before use (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShipping:\u003c\/strong\u003e Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSource:\u003c\/strong\u003e Natural\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eActivity:\u003c\/strong\u003e Cytochalasin E is a fungal toxin which inhibits actin polymerization and blocks the formation of microtubules by inhibiting cell division and cell migration1-4.\u003c\/li\u003e\n\u003c\/ul\u003e \u003ch3\u003eScientific background\u003c\/h3\u003e \u003cp\u003eCytochalasins are a group of fungal toxin metabolites which bind to actin and alter its polymerization. Cytochalasins bind to the barbed end of the actin filament and prevent both the association and dissociation of actin subunits by inhibiting cell microtubule formation, cell division and cell migration.1-4Cytochalasin E induced a rapid and sustained elevation of intracellular free Ca2+ in B lymphocytes by increasing the extracellular Ca2+ influx.5,6\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eLead time:\u003c\/strong\u003e 1-2 Business Days\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eCountry of origin:\u003c\/strong\u003e Israel\/IL\u003c\/p\u003e \u003ch3\u003eApplications key\u003c\/h3\u003e \u003cp\u003eApplication key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eBioassay tested:\u003c\/strong\u003e Yes\u003c\/p\u003e","brand":"Alomone Labs","offers":[{"title":"1 mg \/ 1","offer_id":53249703706989,"sku":"C-550-1MG-1","price":188.0,"currency_code":"USD","in_stock":true},{"title":"1 mg \/ 5","offer_id":53311554486637,"sku":"C-550-1MG-5","price":737.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/C-550_str-1.gif?v=1778544412","url":"https:\/\/www.ebiohippo.com\/products\/cytochalasin-e-bhb21300105","provider":"BioHippo","version":"1.0","type":"link"}