{"product_id":"dapt-bhb11900166","title":"DAPT","description":"\u003cp\u003eDAPT is a potent γ-secretase inhibitor widely used in neuroscience and neurodegenerative disease research. By selectively reducing the production of amyloid-β peptides Aβ40 and Aβ42—key contributors to Alzheimer’s disease pathology—DAPT serves as a critical tool for studying amyloidogenic processing of amyloid precursor protein (APP). It effectively lowers Aβ levels in human primary neuronal cultures and in vivo models, including brain, cerebrospinal fluid, and plasma, without altering non-amyloidogenic APPα and APPβ fragments. DAPT also inhibits Notch signaling, a pathway implicated in neural development and cell fate decisions. Its ability to promote neuronal differentiation makes it valuable for exploring neurogenesis and neural stem cell biology. DAPT is frequently cited in studies investigating the molecular mechanisms of Alzheimer’s disease, neuroinflammation, and synaptic dysfunction.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"5 mg","offer_id":53040946774381,"sku":"SIH-378-5MG","price":93.0,"currency_code":"USD","in_stock":true},{"title":"25 mg","offer_id":53040966861165,"sku":"SIH-378-25MG","price":341.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-378_DAPT_Chemical_Structure.png?v=1771837640","url":"https:\/\/www.ebiohippo.com\/products\/dapt-bhb11900166","provider":"BioHippo","version":"1.0","type":"link"}