{"product_id":"dazap1-antibody-daz-associated-protein-1-bha17136007","title":"DAZAP1 Antibody \/ DAZ associated protein 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eDAZAP1 Antibody \/ DAZ associated protein 1 is a anti-DAZAP1 Rabbit antibody Recombinant Rabbit Monoclonal clone 29D87 supplied in Liquid format. Recommended for workflows such as Western blot (WB) with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e DAZAP1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 29D87, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eDAZAP1 antibody detects DAZ associated protein 1, encoded by the DAZAP1 gene. This protein is an RNA binding factor involved in mRNA processing, alternative splicing, and germ cell development. DAZAP1 antibody provides researchers with a tool to explore reproductive biology, RNA metabolism, and gene regulation. Originally identified as a binding partner of Deleted in Azoospermia (DAZ), DAZAP1 is important in spermatogenesis and fertility.\u003cbr\u003e\u003cbr\u003eDAZ associated protein 1 contains RNA recognition motifs that allow it to bind specific transcripts and influence splicing. Research using DAZAP1 antibody has demonstrated that it regulates pre-mRNA splicing of genes required for germ cell maturation. Its role in testis development makes it critical for fertility, and disruption of DAZAP1 function can impair spermatogenesis. Beyond reproduction, DAZAP1 is expressed in somatic tissues where it contributes to general RNA regulation.\u003cbr\u003e\u003cbr\u003eDAZAP1 interacts with a variety of splicing factors and RNA processing proteins. Studies with DAZAP1 antibody have shown that it modulates exon inclusion or exclusion in target transcripts, thereby shaping tissue-specific gene expression. Alterations in DAZAP1 expression influence cell differentiation and development, suggesting a broader biological impact beyond germline function.\u003cbr\u003e\u003cbr\u003eIn disease contexts, DAZAP1 has been linked to cancer and developmental abnormalities. Research with DAZAP1 antibody has revealed that altered expression affects cell cycle regulation and apoptosis. Its misregulation in tumors suggests a potential role in oncogenesis, possibly through changes in RNA splicing that promote malignant phenotypes. These findings highlight DAZAP1 as both a fertility factor and a regulator of cell fate.\u003cbr\u003e\u003cbr\u003eDAZAP1 antibody is widely applied in western blotting, immunohistochemistry, and immunofluorescence. Western blotting confirms protein size and isoforms, immunohistochemistry demonstrates expression in testis and other tissues, and immunofluorescence shows nuclear localization with splicing speckles. These methods make DAZAP1 antibody versatile in RNA biology research.\u003cbr\u003e\u003cbr\u003eBy providing validated DAZAP1 antibody reagents,\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=DAZAP1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=DAZAP1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=DAZAP1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/DAZAP1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=DAZAP1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047312220525,"sku":"FY13105","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_8af000f4-a781-4366-aa01-d93cb0fe0519.jpg?v=1772019391","url":"https:\/\/www.ebiohippo.com\/products\/dazap1-antibody-daz-associated-protein-1-bha17136007","provider":"BioHippo","version":"1.0","type":"link"}