{"product_id":"dead-box-protein-1-antibody-ddx1-bha17136340","title":"DEAD box protein 1 Antibody \/ DDX1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eDEAD box protein 1 Antibody \/ DDX1 is a anti-DEAD Rabbit antibody Polyclonal (rabbit origin) supplied in Antigen affinity purified format. Recommended for workflows such as Western blot (WB), IHC-P, Flow cytometry (FACS), Immunofluorescence (IF), Immunoprecipitation (IP), ELISA with listed reactivity in Human, Mouse, Rat. Reported localization: Nuclear, cytoplasmic.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e DEAD\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Antigen affinity purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC-P, FACS, IF, IP, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eDEAD box protein 1 (DDX1) is a member of the DEAD-box RNA helicase family, a group of proteins defined by the conserved Asp-Glu-Ala-Asp (DEAD) motif. These proteins participate in a wide variety of cellular processes involving RNA metabolism, including transcription, splicing, mRNA transport, and ribosome biogenesis. DEAD box protein 1 functions as an ATP-dependent RNA helicase, unwinding RNA secondary structures to facilitate proper RNA processing. Researchers often employ a DEAD box protein 1 antibody to study these fundamental processes in molecular and cellular biology.    \u003cp\u003e In addition to its role in RNA metabolism, DEAD box protein 1 has been implicated in maintaining genomic stability. It interacts with DNA repair proteins and contributes to the repair of double-strand breaks, suggesting it acts at the interface between RNA regulation and DNA integrity. By using a DEAD box protein 1 antibody, researchers can explore its functions in cellular stress responses, DNA repair pathways, and cell cycle progression. \u003c\/p\u003e\n\u003cp\u003e Elevated expression of DEAD box protein 1 has been observed in various cancers, linking it to tumor biology and uncontrolled cell proliferation. It has also been connected to viral replication, where it interacts with viral RNA to promote or regulate infection. These diverse roles make it a protein of interest in oncology, virology, and RNA biology. Employing a DEAD box protein 1 antibody provides valuable insights into its activity across multiple biological contexts. \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=DEAD - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=DEAD - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=DEAD - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/DEAD - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=DEAD+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.5mg\/ml if reconstituted with 0.2ml sterile DI water \/ 100 ug","offer_id":53047326376301,"sku":"RQ8922","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_496e4fc7-3009-4eab-8a05-7ab93543045f.jpg?v=1772019452","url":"https:\/\/www.ebiohippo.com\/products\/dead-box-protein-1-antibody-ddx1-bha17136340","provider":"BioHippo","version":"1.0","type":"link"}