{"product_id":"degs1-antibody-des1-dihydroceramide-desaturase-1-bha17135897","title":"DEGS1 Antibody \/ DES1 \/ Dihydroceramide desaturase-1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eDEGS1 Antibody \/ DES1 \/ Dihydroceramide desaturase-1 is a anti-DEGS1 Rabbit antibody Recombinant Rabbit Monoclonal clone 30D03 supplied in Liquid format. Recommended for workflows such as Western blot (WB) with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e DEGS1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 30D03, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eDEGS1 antibody detects Dihydroceramide desaturase 1, encoded by the DEGS1 gene. This enzyme catalyzes the introduction of a trans double bond into dihydroceramide to produce ceramide, a central step in the sphingolipid biosynthesis pathway. Ceramides are essential bioactive lipids involved in regulating apoptosis, autophagy, differentiation, and membrane organization. DEGS1 antibody provides researchers with a valuable tool to study sphingolipid metabolism, cellular signaling, and the pathogenesis of metabolic and neurodegenerative diseases.\u003cbr\u003e\u003cbr\u003eDihydroceramide desaturase 1 resides in the endoplasmic reticulum and is part of a larger network of enzymes controlling sphingolipid levels. By converting dihydroceramide to ceramide, DEGS1 regulates the balance between precursors and bioactive sphingolipids. Research with DEGS1 antibody has shown that altered activity of this enzyme shifts cellular lipid composition, leading to changes in apoptosis sensitivity and membrane structure. Ceramides produced by DEGS1 also participate in signaling pathways that control stress responses, mitochondrial function, and immune activity.\u003cbr\u003e\u003cbr\u003eMutations in DEGS1 cause rare hereditary spastic paraplegia and leukodystrophy, highlighting the enzyme's role in nervous system development and maintenance. Patients with DEGS1 mutations show impaired myelination, progressive neurodegeneration, and developmental delay. Studies using DEGS1 antibody have demonstrated that defective enzyme activity leads to accumulation of dihydroceramides and reduced ceramide production, disrupting neuronal signaling and survival. These findings underscore the enzyme's essential role in neurobiology and its potential as a therapeutic target.\u003cbr\u003e\u003cbr\u003eIn cancer, altered sphingolipid metabolism has been linked to tumor progression and treatment resistance. DEGS1 contributes to the regulation of apoptosis sensitivity, and reduced ceramide levels can enable survival of malignant cells under stress. Research with DEGS1 antibody has associated aberrant expression with poor prognosis in certain cancers, making it a potential biomarker and therapeutic target. Beyond oncology, sphingolipid imbalance has been implicated in metabolic diseases such as diabetes and obesity, further expanding the relevance of DEGS1.\u003cbr\u003e\u003cbr\u003eDEGS1 antibody is applied in western blotting, immunohistochemistry, and lipidomic studies. Western blotting confirms protein expression levels, while immunohistochemistry highlights tissue specific distribution in brain, liver, and metabolic organs. Functional assays using DEGS1 antibody in combination with lipidomics allow researchers to connect enzyme expression with lipid composition changes, providing a systems level view of sphingolipid biology.\u003cbr\u003e\u003cbr\u003eBy supplying validated DEGS1 antibody reagents,\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=DEGS1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=DEGS1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=DEGS1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/DEGS1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=DEGS1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047308321133,"sku":"FY12995","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_5e6332f4-d2eb-4fc9-add9-bb757a6125cf.jpg?v=1772019376","url":"https:\/\/www.ebiohippo.com\/products\/degs1-antibody-des1-dihydroceramide-desaturase-1-bha17135897","provider":"BioHippo","version":"1.0","type":"link"}