{"product_id":"denarase-bhz16500001","title":"DENARASE®- Precision Nuclease for Cleaner Bioprocessing","description":"\u003cstyle\u003e\n  .bhp-desc { font-size: 16px; color: #1b2f42; line-height: 1.75; max-width: 860px; }\n  .bhp-desc h1 { font-size: 26px; font-weight: 700; color: #b7195d; margin: 0 0 20px; line-height: 1.25; }\n  .bhp-desc h2 { font-size: 20px; font-weight: 700; color: #b7195d; margin: 28px 0 10px; line-height: 1.3; }\n  .bhp-desc h3 { font-size: 18px; font-weight: 700; color: #1a5c58; margin: 24px 0 8px; line-height: 1.3; }\n  .bhp-desc p  { margin: 0 0 14px; }\n  .bhp-desc ul { margin: 10px 0 16px 22px; padding: 0; }\n  .bhp-desc ul li { margin-bottom: 10px; }\n  .bhp-desc sup { font-size: 0.72em; vertical-align: super; }\n  .bhp-desc em  { font-style: italic; }\n  .bhp-desc strong { font-weight: 700; color: #1b2f42; }\n  .bhp-desc hr { border: none; border-top: 1px solid #e2e6ea; margin: 28px 0; }\n\u003c\/style\u003e\n\u003cdiv class=\"bhp-desc\"\u003e\n\u003ch1\u003eAbout DENARASE\u003csup\u003e®\u003c\/sup\u003e\n\u003c\/h1\u003e\n\u003ch3\u003eHow DENARASE\u003csup\u003e®\u003c\/sup\u003e works\u003c\/h3\u003e\n\u003cp\u003eDENARASE\u003csup\u003e®\u003c\/sup\u003e specifically hydrolyzes the phosphodiester bonds between nucleotides, leaving smaller fragments of around 3–5 base pairs. The enzyme is active on all forms of nucleic acids including single-stranded, double-stranded, linear, circular, or supercoiled. Best results are obtained when the enzyme is added before the release of DNA.\u003c\/p\u003e\n\u003chr\u003e\n\u003ch3\u003eProduction of DENARASE\u003csup\u003e®\u003c\/sup\u003e\n\u003c\/h3\u003e\n\u003cp\u003eDENARASE\u003csup\u003e®\u003c\/sup\u003e has been developed for use in commercial manufacturing processes of biologicals and complies with EU GMP regulations. The production process uses a gram-positive \u003cem\u003eBacillus\u003c\/em\u003e sp. production host, which minimizes the risks of endotoxins in the product. No antibiotics, Triton X-100, materials with TSE\/BSE risk, or raw materials of animal origin are employed in the manufacture of the product.\u003c\/p\u003e\n\u003chr\u003e\n\u003ch2\u003eDENARASE\u003csup\u003e®\u003c\/sup\u003e is available in two quality grades\u003c\/h2\u003e\n\u003cp\u003eDENARASE\u003csup\u003e®\u003c\/sup\u003e for Research and Development (R\u0026amp;D) use \u0026amp; DENARASE\u003csup\u003e®\u003c\/sup\u003e for manufacturing under GMP.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eDENARASE\u003csup\u003e®\u003c\/sup\u003e \u003cstrong\u003eR\u0026amp;D-grade\u003c\/strong\u003e is produced in conformity with the ISO 9001 standard, with less strict requirements regarding documentation, storage, and distribution.\u003c\/li\u003e\n\u003cli\u003eDENARASE\u003csup\u003e®\u003c\/sup\u003e \u003cstrong\u003eGMP-grade\u003c\/strong\u003e is manufactured under EU GMP conditions.\u003c\/li\u003e\n\u003cli\u003eFrom a technical performance perspective, both quality grades are equal and the parameters on the specification are the same. This allows for a seamless transition from early R\u0026amp;D stage towards biopharmaceutical manufacturing under GMP.\u003c\/li\u003e\n\u003cli\u003eIn order to avoid mix-ups, packaging units of the same size are indicated differently in the product name of the two quality standards: \u003cstrong\u003e1,000 \/ 5,000 kU\u003c\/strong\u003e for R\u0026amp;D-grade DENARASE\u003csup\u003e®\u003c\/sup\u003e and \u003cstrong\u003e1 \/ 5 MU\u003c\/strong\u003e for GMP-grade DENARASE\u003csup\u003e®\u003c\/sup\u003e.\u003cbr\u003e\u003cbr\u003e\u003cbr\u003e\n\u003ch1\u003e\u003ciframe width=\"355\" height=\"199\" src=\"https:\/\/www.youtube.com\/embed\/gzurxSqdAcU\" title=\"DENARASE® Endonuclease for AAV \u0026amp; Viral Vector Production | High-Efficiency DNA Removal\"\u003e\u003c\/iframe\u003e\u003c\/h1\u003e\n\u003cbr\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e","brand":"c-LEcta GmbH","offers":[{"title":"100 kU \/ R\u0026D","offer_id":53273960808813,"sku":"20804-100K","price":599.5,"currency_code":"USD","in_stock":true},{"title":"500 kU \/ R\u0026D","offer_id":53273960841581,"sku":"20804-500K","price":1831.5,"currency_code":"USD","in_stock":true},{"title":"1000 kU \/ R\u0026D","offer_id":53273960874349,"sku":"20804-1000K","price":2673.0,"currency_code":"USD","in_stock":true},{"title":"5000 kU \/ R\u0026D","offer_id":53273960907117,"sku":"20804-5000K","price":8948.5,"currency_code":"USD","in_stock":true},{"title":"1 MU \/ GMP","offer_id":53273960939885,"sku":"20804-1M","price":3156.0,"currency_code":"USD","in_stock":true},{"title":"5 MU \/ GMP","offer_id":53273960972653,"sku":"20804-5M","price":10573.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/DENARASE_GMP_1.webp?v=1777580724","url":"https:\/\/www.ebiohippo.com\/products\/denarase-bhz16500001","provider":"BioHippo","version":"1.0","type":"link"}