{"product_id":"denarase-high-salt-bhz16500002","title":"DENARASE® High Salt – Salt-Tolerant Nuclease for High-Efficiency DNA Removal","description":"\u003cstyle\u003e\n  .bhp-desc { font-size: 16px; color: #1b2f42; line-height: 1.75; max-width: 860px; }\n  .bhp-desc h1 { font-size: 26px; font-weight: 700; color: #1a5c58; margin: 0 0 20px; line-height: 1.25; }\n  .bhp-desc h2 { font-size: 20px; font-weight: 700; color: #1a5c58; margin: 28px 0 10px; line-height: 1.3; }\n  .bhp-desc h3 { font-size: 18px; font-weight: 700; color: #b7195d; margin: 24px 0 8px; line-height: 1.3; }\n  .bhp-desc p  { margin: 0 0 14px; }\n  .bhp-desc ul { margin: 10px 0 16px 22px; padding: 0; }\n  .bhp-desc ul li { margin-bottom: 10px; }\n  .bhp-desc sup { font-size: 0.72em; vertical-align: super; }\n  .bhp-desc em  { font-style: italic; }\n  .bhp-desc strong { font-weight: 700; color: #1b2f42; }\n  .bhp-desc hr { border: none; border-top: 1px solid #e2e6ea; margin: 28px 0; }\n\u003c\/style\u003e\n\u003cdiv class=\"bhp-desc\"\u003e\n\u003ch1\u003eAbout DENARASE\u003csup\u003e®\u003c\/sup\u003e High Salt\u003c\/h1\u003e\n\u003ch3\u003eHow DENARASE\u003csup\u003e®\u003c\/sup\u003e High Salt works\u003c\/h3\u003e\n\u003cp\u003eDENARASE\u003csup\u003e®\u003c\/sup\u003e High Salt is an engineered version of the wild-type \u003cem\u003eSerratia marcescens\u003c\/em\u003e endonuclease. By introducing a few targeted amino acid substitutions, the enzyme was optimized for salt tolerance, retaining activity at higher salt concentrations without losing specificity for nucleic acids. DENARASE\u003csup\u003e®\u003c\/sup\u003e High Salt exhibits high DNA removal activity across a broad range of salt concentrations (0–500 mM NaCl) and pH levels, providing greater flexibility in bioprocessing and enabling seamless integration into existing workflows.\u003c\/p\u003e\n\u003chr\u003e\n\u003ch3\u003eProduction of DENARASE\u003csup\u003e®\u003c\/sup\u003e High Salt\u003c\/h3\u003e\n\u003cp\u003eDENARASE\u003csup\u003e®\u003c\/sup\u003e High Salt is produced using a method nearly identical to the established, patented DENARASE\u003csup\u003e®\u003c\/sup\u003e manufacturing process, based on expression in a gram-positive \u003cem\u003eBacillus\u003c\/em\u003e sp. strain. Developed for commercial production of biologicals, the enzyme is manufactured under GMP conditions complying with EU GMP regulations. Produced without antibiotics, Triton X-100, animal-derived or TSE\/BSE risk raw materials.\u003c\/p\u003e\n\u003chr\u003e\n\u003ch2\u003eDENARASE\u003csup\u003e®\u003c\/sup\u003e High Salt is available in two quality grades\u003c\/h2\u003e\n\u003cp\u003eDENARASE\u003csup\u003e®\u003c\/sup\u003e High Salt for Research and Development (R\u0026amp;D) use \u0026amp; DENARASE\u003csup\u003e®\u003c\/sup\u003e High Salt for manufacturing under GMP.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eDENARASE\u003csup\u003e®\u003c\/sup\u003e High Salt \u003cstrong\u003eR\u0026amp;D-grade\u003c\/strong\u003e: produced under ISO 9001 standard; less stringent requirements for documentation, storage, and distribution.\u003c\/li\u003e\n\u003cli\u003eDENARASE\u003csup\u003e®\u003c\/sup\u003e High Salt \u003cstrong\u003eGMP-grade\u003c\/strong\u003e: manufactured under EU GMP conditions; dedicated regulatory support via US FDA Drug Master File.\u003c\/li\u003e\n\u003cli\u003eBoth quality grades are technically equivalent, enabling a seamless transition from R\u0026amp;D to GMP manufacturing.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003ciframe title=\"High-Performance Endonuclease for Viral Vector Manufacturing | DENARASE High Salt\" src=\"https:\/\/www.youtube.com\/embed\/BvV5MNNzX6k\" height=\"759\" width=\"1349\"\u003e\u003c\/iframe\u003e\u003c\/p\u003e","brand":"c-LEcta GmbH","offers":[{"title":"25 kU \/ R\u0026D","offer_id":53274322796909,"sku":"22002-25k","price":363.0,"currency_code":"USD","in_stock":true},{"title":"100 kU \/ R\u0026D","offer_id":53274322829677,"sku":"22002-100k","price":913.0,"currency_code":"USD","in_stock":true},{"title":"500 kU \/ R\u0026D","offer_id":53274322862445,"sku":"22002-500k","price":2744.5,"currency_code":"USD","in_stock":true},{"title":"1000 kU \/ R\u0026D","offer_id":53274322895213,"sku":"22002-1000k","price":4015.0,"currency_code":"USD","in_stock":true},{"title":"5000 kU \/ R\u0026D","offer_id":53274322927981,"sku":"22002-5000k","price":13579.5,"currency_code":"USD","in_stock":true},{"title":"1 MU \/ GMP","offer_id":53274322960749,"sku":"22002-1M","price":4767.0,"currency_code":"USD","in_stock":true},{"title":"5 MU \/ GMP","offer_id":53274322993517,"sku":"22002-5M","price":15956.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/250313_DENARASEHighSalt_historyslider.webp?v=1777599399","url":"https:\/\/www.ebiohippo.com\/products\/denarase-high-salt-bhz16500002","provider":"BioHippo","version":"1.0","type":"link"}