{"product_id":"dexbrompheniramine-maleate-bhb21902605","title":"Dexbrompheniramine maleate","description":"\u003cdiv class=\"bhp-desc\"\u003e\n\u003cstyle\u003e.bhp-desc{font-size:16px;color:#1a1a1a;line-height:1.7}.bhp-desc h2{font-size:18px;font-weight:700;color:#003366;margin:24px 0 10px;padding-bottom:6px;border-bottom:2px solid #003366}.bhp-desc p{margin:0 0 12px}.bhp-desc .bhp-spec-table{width:100%;border-collapse:collapse;margin:12px 0 18px}.bhp-desc .bhp-spec-table th{width:36%;text-align:left;padding:8px 12px;background:#e8f0fb;color:#003366;font-weight:600;vertical-align:top;border:1px solid #ccd9f0}.bhp-desc .bhp-spec-table td{padding:8px 12px;vertical-align:top;border:1px solid #ccd9f0}.bhp-desc .bhp-warning-box{background:#fff8e6;border-left:4px solid #e6a817;padding:10px 14px;margin:10px 0 14px;border-radius:0 4px 4px 0}.bhp-desc .bhp-cat-pill{display:inline-block;background:#003366;color:#fff;border-radius:20px;padding:3px 12px;font-size:13px;margin-bottom:10px}\u003c\/style\u003e\n\u003cspan class=\"bhp-cat-pill\"\u003eInhibitors\u003c\/span\u003e\u003ch2\u003eCompound Overview\u003c\/h2\u003e\n\u003cp\u003eDexbrompheniramine maleate, also known as (+)-brompheniramine maleate and (S)-brompheniramine maleate, is a dual inhibitor of the histamine H1 receptor and the TRPV1 receptor that can cross the blood-brain barrier. It acts by functionally blocking H1 receptor activity and dose-dependently inhibiting TRPV1-mediated calcium responses, including capsaicin-induced responses. Combined with cimetidine, it eliminates histamine-induced and sham-feeding-induced drinking behavior in rats, whereas given alone it does not induce thirst or alter sham-feeding behavior. It can be used in the research of chronic cough and related pathological mechanisms\u003csup\u003e[1][2][3]\u003c\/sup\u003e. It is supplied as a white to off-white solid (C20H23BrN2O4, MW 435.31) at 98.52% purity.\u003c\/p\u003e\n\u003ch2\u003ePhysical \u0026amp; Chemical Properties\u003c\/h2\u003e\n\u003ctable class=\"bhp-spec-table\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth\u003eCAS Number\u003c\/th\u003e\n\u003ctd\u003e2391-03-9\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eMolecular Formula\u003c\/th\u003e\n\u003ctd\u003eC20H23BrN2O4\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eMolecular Weight\u003c\/th\u003e\n\u003ctd\u003e435.31 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003ePurity\u003c\/th\u003e\n\u003ctd\u003e98.52%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eAppearance\u003c\/th\u003e\n\u003ctd\u003eSolid\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eColor\u003c\/th\u003e\n\u003ctd\u003eWhite to off-white\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eSMILES\u003c\/th\u003e\n\u003ctd\u003eCN(C)CC[C@H](C1=CC=CC=N1)C2=CC=C(C=C2)Br.O=C(O)\/C=C\\C(O)=O\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eSignaling Pathway\u003c\/th\u003e\n\u003ctd\u003eMembrane Transporter\/Ion Channel; Neuronal Signaling; Immunology\/Inflammation; GPCR\/G Protein\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eSolubility\u003c\/th\u003e\n\u003ctd\u003eIn Vitro: DMSO: 100 mg\/mL (229.72 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eStorage\u003c\/th\u003e\n\u003ctd\u003e4°C, sealed storage, away from moisture. In solvent: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture).\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eShipping\u003c\/th\u003e\n\u003ctd\u003eRoom temperature in continental US; may vary elsewhere.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003ch2\u003eLiterature Cited\u003c\/h2\u003e\n\u003cp style=\"font-size:14px;color:#555;margin:0 0 10px\"\u003e\u003cem\u003eSources cited in this description and in the In Vitro \u0026amp; In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e [1]. \u003ca target=\"_blank\" rel=\"noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/4059386\"\u003eKraly FS, et al. Histamine and serotonin independently elicit drinking in the rat. Physiol Behav. 1985;34(6):963-967.\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e [2]. Singh U, et al. Investigation of the Pathomechanism of Chronic Cough Using an In Vitro Approach[J]. Clinical and Experimental Allergy, 2025, 55(3): 247.\u003c\/p\u003e\n\u003cp\u003e [3]. \u003ca target=\"_blank\" rel=\"noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/6721931\"\u003eKraly FS, et al. Preabsorptive pregastric vagally mediated histaminergic component of drinking elicited by eating in the rat. Behav Neurosci. 1984;98(2):349-355.\u003c\/a\u003e\u003c\/p\u003e\n\u003ch2\u003eSafety\u003c\/h2\u003e\n\u003cdiv class=\"bhp-warning-box\"\u003e\u003cp\u003e\u003cstrong\u003eFor Research Use Only.\u003c\/strong\u003e Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.\u003c\/p\u003e\u003c\/div\u003e\n\u003c\/div\u003e","brand":"MedChemExpress (MCE)","offers":[{"title":"5 mg","offer_id":67604959101293,"sku":"HY-A0191A-5MG","price":120.0,"currency_code":"USD","in_stock":true},{"title":"10 mg","offer_id":67605424669037,"sku":"HY-A0191A-10MG","price":180.0,"currency_code":"USD","in_stock":true},{"title":"25 mg","offer_id":67605424701805,"sku":"HY-A0191A-25MG","price":360.0,"currency_code":"USD","in_stock":true},{"title":"50 mg","offer_id":67605424734573,"sku":"HY-A0191A-50MG","price":540.0,"currency_code":"USD","in_stock":true},{"title":"100 mg","offer_id":67605424767341,"sku":"HY-A0191A-100MG","price":810.0,"currency_code":"USD","in_stock":true},{"title":"200 mg","offer_id":67605424800109,"sku":"HY-A0191A-200MG","price":0.0,"currency_code":"USD","in_stock":true},{"title":"500 mg","offer_id":67605424832877,"sku":"HY-A0191A-500MG","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/hy-a0191a.gif?v=1790973095","url":"https:\/\/www.ebiohippo.com\/products\/dexbrompheniramine-maleate-bhb21902605","provider":"BioHippo","version":"1.0","type":"link"}