{"product_id":"dgat1-antibody-diacylglycerol-o-acyltransferase-1-bha17136333","title":"DGAT1 Antibody \/ Diacylglycerol O-acyltransferase 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eDGAT1 Antibody \/ Diacylglycerol O-acyltransferase 1 is a anti-DGAT1 Rabbit antibody Recombinant Rabbit Monoclonal clone 23D11 supplied in Purified format. Recommended for workflows such as Western blot (WB), IHC-P with listed reactivity in Human. Reported localization: Cytoplasm (ER).\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e DGAT1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 23D11, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC-P\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eDGAT1 (Diacylglycerol O-acyltransferase 1) is an integral membrane enzyme that catalyzes the final step in triacylglycerol biosynthesis by converting diacylglycerol and acyl-CoA into triglycerides. This reaction is central to lipid metabolism, energy storage, and dietary fat absorption. A DGAT1 antibody is frequently used to study lipid homeostasis and metabolic regulation.    \u003cp\u003e DGAT1 is expressed in many tissues, with particularly high levels in adipose tissue, liver, and small intestine. It plays essential roles in maintaining lipid droplet formation, regulating intestinal fat absorption, and supporting energy balance. Alterations in DGAT1 function have been associated with metabolic disorders, obesity, and lipodystrophy. Employing a DGAT1 antibody allows researchers to investigate its enzymatic function and disease relevance. \u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=DGAT1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=DGAT1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=DGAT1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/DGAT1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=DGAT1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047325589869,"sku":"RQ8914","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_80bccbbb-2b2c-4114-8a79-258af6238fca.jpg?v=1772019447","url":"https:\/\/www.ebiohippo.com\/products\/dgat1-antibody-diacylglycerol-o-acyltransferase-1-bha17136333","provider":"BioHippo","version":"1.0","type":"link"}