{"product_id":"dl-ap3-bhb21300127","title":"DL-AP3","description":"\u003ch3\u003eProduct details\u003c\/h3\u003e \u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eChemical name:\u003c\/strong\u003e 2-amino-3-phosphonopropanoic acid.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAlso known as:\u003c\/strong\u003e DL-2-Amino-3-phosphonopropionic acid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS number:\u003c\/strong\u003e 5652-28-8\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular formula:\u003c\/strong\u003e C3H8NO5P.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;97%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConcentration:\u003c\/strong\u003e 0.1-10 mM.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized powder.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSolubility:\u003c\/strong\u003e Soluble in water, 1eq NaOH and aqueous buffers.Centrifuge all product preparations before use (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReconstitution:\u003c\/strong\u003e Soluble in water, 1eq NaOH and aqueous buffers.Centrifuge all product preparations before use (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShipping:\u003c\/strong\u003e Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e mGluR1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSource:\u003c\/strong\u003e Synthetic\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eActivity:\u003c\/strong\u003e DL-AP3 is a selective competitive antagonist of group I metabotropic glutamate receptors, at 1 mM suppressing mGluR1 response in an agonist dependent manner1.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAlternative names:\u003c\/strong\u003e DL-2-Amino-3-phosphonopropionic acid\u003c\/li\u003e\n\u003c\/ul\u003e \u003ch3\u003eScientific background\u003c\/h3\u003e \u003cp\u003eDL-AP3 is a racemic compound of 2-amino-3-phosphonopropionic acid that acts as a potent and competitive antagonist of mGluR1 receptors. It demonstrates an IC50 value of 1 mM for rat mGluR1 when challenged with glutamate2. DL-AP3 has neuroprotective effects in the gerbil model of global ischemia1,2.Glutamate is the most abundant excitatory neurotransmitter in the central nervous system. It modulates the activity of many types of synapses by activating, in part, metabotropic glutamate receptors (mGluRs), members of the G-protein coupled receptor (GPCR) superfamily. These receptors are divided into three groups based on sequence homology with a total of eight subtypes, mGluR1 to mGluR8. Type 1 mGluRs are mainly detected on post-synaptic neurons and affect the fate of neuronal progenitor cells and neural stem cells, and are important for the formation of the hippocampus3.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eLead time:\u003c\/strong\u003e 1-2 Business Days\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eCountry of origin:\u003c\/strong\u003e Israel\/IL\u003c\/p\u003e \u003ch3\u003eApplications key\u003c\/h3\u003e \u003cp\u003eApplication key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eBioassay tested:\u003c\/strong\u003e Yes\u003c\/p\u003e","brand":"Alomone Labs","offers":[{"title":"100 mg \/ 1","offer_id":53249707049325,"sku":"D-275-100MG-1","price":66.0,"currency_code":"USD","in_stock":true},{"title":"250 mg \/ 1","offer_id":53311555764589,"sku":"D-275-250MG-1","price":129.0,"currency_code":"USD","in_stock":true},{"title":"50 mg \/ 1","offer_id":53311555797357,"sku":"D-275-50MG-1","price":50.0,"currency_code":"USD","in_stock":true},{"title":"500 mg \/ 1","offer_id":53311555830125,"sku":"D-275-500MG-1","price":219.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/D-275_gr.gif?v=1778544408","url":"https:\/\/www.ebiohippo.com\/products\/dl-ap3-bhb21300127","provider":"BioHippo","version":"1.0","type":"link"}