{"product_id":"dna-rna-damage-antibody-bha11900800","title":"MOLECULAR SIGNATURE® DNA\/RNA Damage Antibody","description":"\u003cp\u003eDNA and RNA damage are critical molecular events that contribute to the onset and progression of neurodegenerative diseases. These lesions arise from both endogenous metabolic processes and environmental stressors, including oxidative stress, inflammation, and exposure to neurotoxins. In neurons—cells with limited regenerative capacity—such damage can have profound and lasting effects.\u003c\/p\u003e\n\n\u003cp\u003eReactive oxygen and nitrogen species (RONS), such as hydroxyl radicals and peroxynitrite, induce oxidative modifications to nucleic acids. Key biomarkers of this damage include 8-hydroxyguanine (8-OHG), 8-hydroxy-2'-deoxyguanosine (8-OHdG), and 8-hydroxyguanosine (8-OHG), which are associated with mutagenic base transversions and impaired transcriptional fidelity. These lesions disrupt gene expression, mitochondrial function, and synaptic signaling—hallmarks of neurodegenerative pathology.\u003c\/p\u003e\n\n\u003cp\u003eIn diseases such as Alzheimer’s, Parkinson’s, and ALS, persistent DNA and RNA damage activates neuroinflammatory pathways and accelerates neuronal loss. Moreover, the failure of DNA repair mechanisms exacerbates genomic instability, further compromising neural integrity.\u003c\/p\u003e\n\n\u003cp\u003eUnderstanding the molecular signatures of nucleic acid damage offers valuable insights into disease mechanisms and provides a foundation for developing diagnostic biomarkers and targeted therapies aimed at preserving genomic stability and neuronal function.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"100 ug \/ Unconjugated","offer_id":53040790077805,"sku":"SMC-155D","price":312.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 390","offer_id":53040836542829,"sku":"SMC-155D-A390","price":367.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 488","offer_id":53040836575597,"sku":"SMC-155D-A488","price":366.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 594","offer_id":53040836608365,"sku":"SMC-155D-A594","price":366.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ APC","offer_id":53040836641133,"sku":"SMC-155D-APC","price":365.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ BI","offer_id":53040836673901,"sku":"SMC-155D-BI","price":361.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ FITC","offer_id":53040836706669,"sku":"SMC-155D-FITC","price":357.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ HRP","offer_id":53040836739437,"sku":"SMC-155D-HRP","price":352.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ PCP","offer_id":53040836772205,"sku":"SMC-155D-PCP","price":365.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ RPE","offer_id":53040836804973,"sku":"SMC-155D-RPE","price":362.0,"currency_code":"USD","in_stock":true},{"title":"12 ug \/ Unconjugated","offer_id":53040836837741,"sku":"SMC-155S","price":45.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SMC-155_DNA-Damage_Antibody_15A3_IHC_Mouse_Retinal-Injury-Model_1.png?v=1771832131","url":"https:\/\/www.ebiohippo.com\/products\/dna-rna-damage-antibody-bha11900800","provider":"BioHippo","version":"1.0","type":"link"}