{"product_id":"dnaja4-antibody-dnaj-homolog-subfamily-a-member-4-bha17136208","title":"DNAJA4 Antibody \/ DnaJ homolog subfamily A member 4","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eDNAJA4 Antibody \/ DnaJ homolog subfamily A member 4 is a anti-DNAJA4 Rabbit antibody Recombinant Rabbit Monoclonal clone 30D35 supplied in Liquid format. Recommended for workflows such as Western blot (WB), Immunoprecipitation (IP) with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e DNAJA4\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 30D35, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IP\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eDNAJA4 antibody detects DnaJ homolog subfamily A member 4, encoded by the DNAJA4 gene. DnaJ homolog subfamily A member 4 is a co-chaperone of the Hsp40\/DnaJ family that regulates Hsp70 activity, ensuring proper protein folding, degradation, and cellular stress responses. DNAJA4 antibody provides researchers with a valuable reagent to study chaperone biology, protein homeostasis, and stress adaptation.\u003cbr\u003e\u003cbr\u003eDnaJ homolog subfamily A member 4 contains a J domain that interacts with Hsp70 family chaperones to stimulate ATP hydrolysis and substrate binding. Research using DNAJA4 antibody has shown that it guides Hsp70 to specific client proteins, thereby influencing folding efficiency and preventing aggregation. This co-chaperone function is critical for maintaining proteostasis under normal and stress conditions.\u003cbr\u003e\u003cbr\u003eStudies with DNAJA4 antibody have revealed important roles in cardiac and muscle physiology. DNAJA4 is enriched in cardiomyocytes, where it supports folding of contractile proteins and protects cells from stress-induced apoptosis. Loss of DNAJA4 function impairs sarcomeric organization and reduces cardiac performance. These findings highlight the relevance of DNAJA4 in cardiovascular health.\u003cbr\u003e\u003cbr\u003eDysregulation of DnaJ homolog subfamily A member 4 contributes to disease. Research using DNAJA4 antibody has shown that altered expression affects cell survival under stress, contributing to pathologies such as cardiomyopathy and neurodegeneration. Because DNAJA4 modulates stress response pathways, it is a candidate biomarker and therapeutic target in diseases linked to proteostasis failure.\u003cbr\u003e\u003cbr\u003eDNAJA4 antibody is widely applied in western blotting, immunohistochemistry, and immunofluorescence. Western blotting detects multiple isoforms and stress-induced expression, immunohistochemistry reveals tissue distribution in heart and muscle, and immunofluorescence demonstrates cytoplasmic localization associated with chaperone networks. These approaches make DNAJA4 antibody essential for research on molecular chaperones.\u003cbr\u003e\u003cbr\u003eBy providing validated DNAJA4 antibody reagents,\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=DNAJA4 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=DNAJA4 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=DNAJA4 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/DNAJA4 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=DNAJA4+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047321821549,"sku":"FY13306","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_48b888fb-ba31-4230-a602-d8ec44e5d57f.jpg?v=1772019427","url":"https:\/\/www.ebiohippo.com\/products\/dnaja4-antibody-dnaj-homolog-subfamily-a-member-4-bha17136208","provider":"BioHippo","version":"1.0","type":"link"}