{"product_id":"dnajc12-antibody-dnaj-homolog-subfamily-c-member-12-bha17130351","title":"DNAJC12 Antibody \/ DnaJ homolog subfamily C member 12","description":"\u003ch2\u003eOverview\u003c\/h2\u003e \u003cp\u003eDNAJC12 Antibody \/ DnaJ homolog subfamily C member 12 is an antibody targeting \u003cstrong\u003eDNAJC12\u003c\/strong\u003e, raised in \u003cstrong\u003eRabbit\u003c\/strong\u003e for protein detection and localization studies where these specifications are required.\u003c\/p\u003e \u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e \u003cul\u003e \u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e DNAJC12.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eAntibody identity:\u003c\/strong\u003e Recombinant Rabbit Monoclonal; Clone 29D24; Rabbit IgG.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eConjugate\/label:\u003c\/strong\u003e Unconjugated (affects detection chemistry and multiplex compatibility).\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Purified.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eSpecies reactivity:\u003c\/strong\u003e Human.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eListed applications:\u003c\/strong\u003e WB (refer to on-page specifications for application-specific guidance).\u003c\/li\u003e \u003c\/ul\u003e  \u003ch2\u003eBiological background\u003c\/h2\u003e \u003cp\u003eThe DnaJ homolog subfamily C member 12 protein, also known as DNAJC12, is a member of the DnaJ\/Hsp40 family of proteins. These proteins are involved in assisting in the folding and unfolding of other proteins, as well as in regulating cellular processes such as protein degradation and transportation.  One of the key functions of DNAJC12 is its involvement in protein quality control. It acts as a chaperone protein, helping to refold misfolded proteins and target damaged proteins for degradation. This is essential for maintaining the health and functionality of cells, as misfolded proteins can lead to cellular dysfunction and disease.  Additionally, DNAJC12 has been implicated in various disease processes, including neurodegenerative disorders and cancer. Studies have shown that alterations in the expression or function of this protein can contribute to the development of these conditions, highlighting the importance of understanding its role in cellular physiology.\u003c\/p\u003e \u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eComparative expression profiling across cell types, tissues, or perturbations (e.g., drug treatment, genetic editing, or differentiation).\u003c\/li\u003e \u003cli\u003eSubcellular localization and trafficking studies, including co-localization with pathway markers in microscopy-based assays.\u003c\/li\u003e \u003cli\u003eIntegration of protein-level measurements with transcriptomics or proteomics to relate abundance to regulation and phenotype.\u003c\/li\u003e \u003c\/ul\u003e \u003ch2\u003eCommon research applications\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eWestern blotting: researchers commonly compare relative signal levels across conditions and use appropriate negative\/positive controls for interpretation.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eInterpretation should account for antibody-dependent factors such as epitope accessibility, isoforms, and sample preparation differences across workflows.\u003c\/p\u003e \u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e \u003cul\u003e \u003cli\u003e\n\u003cstrong\u003eIsoforms and PTMs:\u003c\/strong\u003e many targets have multiple isoforms and post-translational modifications that can shift apparent signal or localization; interpret bands\/signals accordingly.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eEpitope context:\u003c\/strong\u003e binding can depend on protein conformation and sample processing; region information in the title\/immunogen can help anticipate what may be detected.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eSpecies differences:\u003c\/strong\u003e predicted or validated reactivity may vary by ortholog sequence and sample context; confirm in your model system.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eControl concepts:\u003c\/strong\u003e include negative controls (no-primary\/isotype), and where possible genetic controls (KO\/KD) or independent antibodies to strengthen conclusions.\u003c\/li\u003e \u003c\/ul\u003e \u003c!-- Sources (internal): - UniProtKB entry Q9UKB3 — UniProt — https:\/\/www.uniprot.org\/uniprotkb\/Q9UKB3 - Gene search: DNAJC12 — NCBI Gene — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=DNAJC12 - Ensembl search: DNAJC12 — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=DNAJC12 - PubMed search: DNAJC12 antibody — PubMed — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=DNAJC12+antibody - Reactome search: DNAJC12 — Reactome — https:\/\/reactome.org\/content\/query?q=DNAJC12 --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53046491054445,"sku":"RQ8797","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_c0f1ef97-00f5-46b1-8835-31b32d1c74bf.jpg?v=1772000920","url":"https:\/\/www.ebiohippo.com\/products\/dnajc12-antibody-dnaj-homolog-subfamily-c-member-12-bha17130351","provider":"BioHippo","version":"1.0","type":"link"}