{"product_id":"dnmt2-antibody-dna-methyltransferase-2-trdmt1-bha17135118","title":"Dnmt2 Antibody \/ DNA methyltransferase 2 \/ TRDMT1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eDnmt2 Antibody \/ DNA methyltransferase 2 \/ TRDMT1 is an antibody targeting \u003cstrong\u003eDnmt2\u003c\/strong\u003e. Host: \u003cstrong\u003eRabbit\u003c\/strong\u003e. Polyclonal. Format: Lyophilized. Applications: WB, FACS, ELISA.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e Dnmt2.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunogen:\u003c\/strong\u003e E.coli-derived mouse DNMT2\/TRDMT1 recombinant protein (Position: M16-E391) was used as the immunogen for the Dnmt2 anti….\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSpecies reactivity:\u003c\/strong\u003e Mouse, Rat.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConjugate:\u003c\/strong\u003e Unconjugated (no label listed).\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background (from provided description)\u003c\/h2\u003e\u003cp\u003eDNMT2 antibody detects DNA methyltransferase homolog 2, encoded by the TRDMT1 gene on chromosome 10p15.1. DNMT2 antibody is applied in research on epigenetics, RNA modification, and gene regulation. Although named DNA methyltransferase 2, DNMT2 primarily functions as an RNA methyltransferase that catalyzes cytosine-5 methylation at tRNA-Asp and other tRNAs, influencing translation fidelity and stability.\u003c\/p\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWB:\u003c\/strong\u003e relative abundance and band pattern assessment using appropriate controls.\u003c\/li\u003e\u003c\/ul\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eAccount for isoforms, paralogs, and post-translational modifications when interpreting signal.\u003c\/li\u003e\n\u003cli\u003eSupport specificity with biological controls (e.g., KO\/KD where available) and technical controls (e.g., secondary-only\/isotype).\u003c\/li\u003e\n\u003c\/ul\u003e\u003c!-- Sources (internal): - UniProt Knowledgebase (UniProt) – https:\/\/www.uniprot.org\/ - NCBI Gene (NIH\/NLM) – https:\/\/www.ncbi.nlm.nih.gov\/gene\/ - ZFIN – https:\/\/zfin.org\/ - Ensembl – https:\/\/www.ensembl.org\/ - Nature Methods (2015): A proposal for validation of antibodies – https:\/\/www.nature.com\/articles\/nmeth.3230 --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53046719676781,"sku":"FY12215","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_9e0a6b85-755a-433b-b015-4b9bde3f0c21.jpg?v=1782236975","url":"https:\/\/www.ebiohippo.com\/products\/dnmt2-antibody-dna-methyltransferase-2-trdmt1-bha17135118","provider":"BioHippo","version":"1.0","type":"link"}