{"product_id":"dot1l-antibody-fitc-conjugated-bha10528070","title":"DOT1L Antibody, FITC conjugated","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eThis polyclonal anti-DOT1L antibody raised in Rabbit, conjugated with FITC. Designed to detect DOT1L in Human for epigenetics and nuclear signaling research.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunogen:\u003c\/strong\u003e Recombinant Human Histone-lysine N-methyltransferase, H3 lysine-79 specific protein (331-484AA) — determines epitope; confirm sample prep compatibility.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHost (Rabbit):\u003c\/strong\u003e Requires anti-rabbit-IgG secondary matching isotype IgG.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePolyclonal:\u003c\/strong\u003e Multiple epitopes = robust signal; lot-to-lot variability — include controls.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIsotype (IgG):\u003c\/strong\u003e Match secondary, Protein A\/G, and isotype controls to IgG.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurification (Protein G purification):\u003c\/strong\u003e Enriches Ig classes; reduces non-specific background.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFITC:\u003c\/strong\u003e Direct fluorescence (Ex490\/Em525); protect from light; use antifade.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cp\u003e\u003cstrong\u003eDOT1L\u003c\/strong\u003e (also: Disrupter of telomere silencing protein 1, DOT 1, DOT1, DOT1 like, DOT1 like histone H3 methyltransferase (S. cerevisiae), DOT1 like histone H3 methyltransferase, DOT1 like histone H3K79 methyltransferase, DOT1 like protein , DOT1, S. cerevisiae, homolog of, DOT1-like protein, DOT1L, DOT1L_HUMAN, EC 2.1.1.43, H3 K79 HMTase, H3 lysine-79 specific, H3-K79-HMTase, Histone H3 K79 methyltransferase, Histone H3 methyltransferase, Histone H3 methyltransferase DOT1-like, Histone H3-K79 methyltransferase, Histone lysine N methyltransferase H3 lysine 79 specific, Histone methyltransferase DOT1L, Histone-lysine N-methyltransferase, KIAA1814, KMT4, Lysine N methyltransferase 4, Lysine N-methyltransferase 4) — studied in Human systems. Expression, localization, and PTMs vary across cell types and disease states. Consult UniProt, NCBI Gene, and primary literature for current DOT1L annotation relevant to epigenetics and nuclear signaling.\u003c\/p\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003eRefer to product documentation for confirmed application data.\u003c\/li\u003e\u003c\/ul\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eIsotype controls:\u003c\/strong\u003e IgG from Rabbit at equivalent concentration.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCross-reactivity:\u003c\/strong\u003e Polyclonal: validate with KO\/KD controls.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMatrix effects:\u003c\/strong\u003e Verify dilution linearity in your sample matrix.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReactivity:\u003c\/strong\u003e Confirmed for Human; extrapolation requires validation.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cem\u003eThis product is a polyclonal antibody purified from rabbit antiserum.\u003c\/em\u003e\u003c\/p\u003e\u003c!-- Sources: UniProt, NCBI Gene, Cusabio, Human Protein Atlas, PubMed --\u003e","brand":"CUSABIO TECHNOLOGY LLC","offers":[{"title":"50 ug","offer_id":53240812011885,"sku":"CSB-PA848418LC01HU-50UG","price":166.0,"currency_code":"USD","in_stock":true},{"title":"100 ug","offer_id":53240914149741,"sku":"CSB-PA848418LC01HU-100UG","price":299.0,"currency_code":"USD","in_stock":true}],"url":"https:\/\/www.ebiohippo.com\/products\/dot1l-antibody-fitc-conjugated-bha10528070","provider":"BioHippo","version":"1.0","type":"link"}