{"product_id":"doxorubicin-hydrochloride-bhb11900178","title":"Doxorubicin Hydrochloride","description":"\u003cp\u003eDoxorubicin Hydrochloride is a DNA-intercalating chemotherapeutic agent known for its broad-spectrum anticancer activity. In neuroscience, Doxorubicin is used to model neurotoxicity and investigate mechanisms of neuronal damage, particularly in studies of chemotherapy-induced cognitive impairment (\"chemo brain\"). It induces apoptosis by inhibiting topoisomerase II and disrupting DNA replication and transcription. Doxorubicin also triggers oxidative stress and mitochondrial dysfunction—key features of neurodegenerative diseases. Although its clinical use is limited by systemic toxicity, including hematologic and cardiac effects, its ability to induce autophagy and cell death pathways makes it a valuable tool for studying neuronal stress responses and neurodegeneration in vitro and in vivo.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"10 mg","offer_id":53040946413933,"sku":"SIH-390-10MG","price":132.0,"currency_code":"USD","in_stock":true},{"title":"50 mg","offer_id":53040968302957,"sku":"SIH-390-50MG","price":474.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-390_Doxorubicin_Hydrochloride_Chemical_Structure.png?v=1771837646","url":"https:\/\/www.ebiohippo.com\/products\/doxorubicin-hydrochloride-bhb11900178","provider":"BioHippo","version":"1.0","type":"link"}