{"product_id":"dqp-1105-bhb21300124","title":"DQP-1105","description":"\u003ch3\u003eProduct details\u003c\/h3\u003e \u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eChemical name:\u003c\/strong\u003e 4-[(3Z)-5-(4-bromophenyl)-3-(6-methyl-2-oxo-4-phenylquinolin-3-ylidene)pyrazolidin-1-yl]-4-oxobutanoic acid.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS number:\u003c\/strong\u003e 380560-89-4\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular formula:\u003c\/strong\u003e C29H24BrN3O4.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;98%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConcentration:\u003c\/strong\u003e 1-20 µM.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized Powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSolubility:\u003c\/strong\u003e Soluble up to 100 mM in DMSO. Centrifuge all products before handling (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReconstitution:\u003c\/strong\u003e Soluble up to 100 mM in DMSO. Centrifuge all products before handling (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShipping:\u003c\/strong\u003e Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e GluN2D and GluN2C-containing NMDA receptors\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSource:\u003c\/strong\u003e Synthetic\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eActivity:\u003c\/strong\u003e DQP-1105 is a potent, noncompetitive NMDA receptor antagonist, exhibiting significant selectivity for NR2D and NR2C-containing receptors (IC50 = 2.7 µM and 8.5 µM, respectively) over NR2B and NR2A-containing receptors (IC50 = 121 µM and 206 µM, respectively)1.\u003c\/li\u003e\n\u003c\/ul\u003e \u003ch3\u003eScientific background\u003c\/h3\u003e \u003cp\u003eDQP-1105 is a potent and noncompetitive antagonist of GluN2D and GluN2C-containing N-methyl-d-aspartate (NMDA) receptors displaying IC50 values of 2.7 µM and 8.5 µM towards NR2D and NR2C-containing receptors, respectively1. DQP-1105 exhibits significant selectivity towards these receptors over NR2B and NR2A-containing receptors. DQP-105 inhibits the pregating step without changing the stability of the open pore conformation.NMDA receptors are heterotetrameric channels formed by the assembly of two obligatory GluN1 and two GluN2\/GluN3 subunits. They play an important role in a variety of cellular processes and brain functions such as synaptic plasticity, addiction and stroke. NMDA receptors mediate physiological functions such as learning and memory formation, glutamate excitotoxicity and are involved in many neurodegenerative conditions including Alzheimer's disease2.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eLead time:\u003c\/strong\u003e 1-2 Business Days\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eCountry of origin:\u003c\/strong\u003e Israel\/IL\u003c\/p\u003e \u003ch3\u003eApplications key\u003c\/h3\u003e \u003cp\u003eApplication key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eBioassay tested:\u003c\/strong\u003e Yes\u003c\/p\u003e","brand":"Alomone Labs","offers":[{"title":"10 mg \/ 1","offer_id":53249703903597,"sku":"D-210-10MG-1","price":168.0,"currency_code":"USD","in_stock":true},{"title":"25 mg \/ 1","offer_id":53311555109229,"sku":"D-210-25MG-1","price":373.0,"currency_code":"USD","in_stock":true},{"title":"5 mg \/ 1","offer_id":53311555141997,"sku":"D-210-5MG-1","price":117.0,"currency_code":"USD","in_stock":true},{"title":"50 mg \/ 1","offer_id":53311555174765,"sku":"D-210-50MG-1","price":672.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/D-210_str-2.gif?v=1778544417","url":"https:\/\/www.ebiohippo.com\/products\/dqp-1105-bhb21300124","provider":"BioHippo","version":"1.0","type":"link"}