{"product_id":"dynlt1-antibody-tctex1-bha17135457","title":"DYNLT1 Antibody \/ TCTEX1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eDYNLT1 Antibody \/ TCTEX1 is a anti-DYNLT1 Rabbit antibody Recombinant Rabbit Monoclonal clone 30D84 supplied in Liquid format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP) with listed reactivity in Human, Mouse.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e DYNLT1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 30D84, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, ICC, IF, IP\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eDYNLT1 antibody detects dynein light chain Tctex type 1, a component of the cytoplasmic dynein complex encoded by the DYNLT1 gene. Cytoplasmic dynein is a multisubunit motor protein responsible for retrograde transport along microtubules. The Tctex type light chains, including DYNLT1, provide cargo binding specificity and regulatory interactions that guide dynein mediated transport of vesicles, organelles, and signaling proteins. Through these functions, DYNLT1 contributes to intracellular trafficking, neuronal transport, and cell cycle regulation.\u003cbr\u003e\u003cbr\u003eDYNLT1 antibody is widely used in cell biology, neuroscience, and developmental research. In neurons, DYNLT1 mediates retrograde transport of signaling endosomes, mitochondria, and synaptic vesicles. This process is essential for synaptic maintenance, neuronal survival, and communication between axons and cell bodies. Disruption of DYNLT1 impairs axonal transport and has been linked to neurodevelopmental and neurodegenerative diseases. By detecting DYNLT1, researchers can evaluate the molecular basis of dynein cargo interactions and their impact on neuronal function.\u003cbr\u003e\u003cbr\u003e Western blot assays reveal DYNLT1 protein bands in cell lysates and neuronal extracts. Immunohistochemistry maps DYNLT1 expression in brain and spinal cord tissues, while immunofluorescence highlights punctate localization consistent with vesicular transport complexes. These methods make DYNLT1 antibody a versatile tool for analyzing retrograde trafficking pathways.\u003cbr\u003e\u003cbr\u003eDYNLT1 also plays roles in viral infection, where it is hijacked by pathogens to facilitate retrograde transport of viral components. Additionally, DYNLT1 has been implicated in mitotic spindle positioning, apoptosis regulation, and intracellular signaling. By applying DYNLT1 antibody, scientists can investigate how dynein light chain proteins integrate diverse cellular processes through transport regulation.\u003cbr\u003e\u003cbr\u003eDYNLT1 antibody from\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=DYNLT1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=DYNLT1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=DYNLT1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/DYNLT1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=DYNLT1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047292625261,"sku":"FY12554","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_c7aa4d86-6419-4050-b62c-8046df9cac84.jpg?v=1772019306","url":"https:\/\/www.ebiohippo.com\/products\/dynlt1-antibody-tctex1-bha17135457","provider":"BioHippo","version":"1.0","type":"link"}