{"product_id":"dyrk2-positive-control-for-stj500809-antibody-stj505505-bhp15502029","title":"DYRK2 Positive Control for STJ500809 antibody (STJ505505)","description":"\u003cstyle\u003e\n.bhp-desc{font-size:16px;color:#1a1a1a;line-height:1.7}\n.bhp-desc h2{font-size:18px;font-weight:700;color:#003366;margin:24px 0 10px;padding-bottom:6px;border-bottom:2px solid #003366}\n.bhp-desc p{margin:0 0 12px}\n.bhp-desc .bhp-spec-table{width:100%;border-collapse:collapse;margin:12px 0 18px}\n.bhp-desc .bhp-spec-table th{width:36%;text-align:left;padding:8px 12px;background:#e8f0fb;color:#003366;font-weight:600;vertical-align:top;border:1px solid #ccd9f0}\n.bhp-desc .bhp-spec-table td{padding:8px 12px;vertical-align:top;border:1px solid #ccd9f0}\n.bhp-desc .bhp-qc-badge{display:inline-block;background:#e6f4ea;color:#1a7a3c;border:1px solid #a8d5b5;border-radius:4px;padding:6px 14px;font-size:14px;font-weight:600}\n.bhp-desc .bhp-warning-box{background:#fff8e6;border-left:4px solid #e6a817;padding:10px 14px;margin:10px 0 14px;border-radius:0 4px 4px 0}\n.bhp-desc .bhp-cat-pill{display:inline-block;background:#003366;color:#fff;border-radius:20px;padding:3px 12px;font-size:13px;margin-bottom:10px}\n\u003c\/style\u003e\n\u003cdiv class=\"bhp-desc\"\u003e\n\u003ch2\u003eScientific Background\u003c\/h2\u003e\n\u003cp\u003eDYRK2 (Dual-specificity tyrosine phosphorylation-regulated kinase 2) is a serine\/threonine kinase regulating cell cycle checkpoints, apoptosis, and 26S proteasomal activity. DYRK2 functions as a tumour suppressor by phosphorylating p53 (Ser46) and TERT, and is frequently downregulated in cancer through promoter methylation or ubiquitin-mediated degradation.\u003c\/p\u003e\n\u003ch2\u003eProduct Description\u003c\/h2\u003e\n\u003cspan class=\"bhp-cat-pill\"\u003ePositive Control Peptide\u003c\/span\u003e\n\u003cp\u003eThis positive control is supplied as 100 µL of pre-denatured protein in Laemmli SDS-PAGE sample buffer (SDS, glycerol, Tris pH 6.8, beta-mercaptoethanol). It is designed for direct loading onto SDS-PAGE gels without further preparation, enabling consistent Western Blot positive controls in the same run as experimental samples.\u003c\/p\u003e\n\n\u003ch2\u003eProduct Specifications\u003c\/h2\u003e\n\u003ctable class=\"bhp-spec-table\"\u003e\n  \u003ctr\u003e\n\u003cth\u003eUniProt ID\u003c\/th\u003e\n\u003ctd\u003eQ92630\u003c\/td\u003e\n\u003c\/tr\u003e\n  \u003ctr\u003e\n\u003cth\u003eFormulation\u003c\/th\u003e\n\u003ctd\u003eProvided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli s buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is empirically adjusted to get a clear band with signal to noise ratio for its corresponding antibody.\u003c\/td\u003e\n\u003c\/tr\u003e\n  \u003ctr\u003e\n\u003cth\u003eRecommended Dilution\u003c\/th\u003e\n\u003ctd\u003eWB: 1:500\u003c\/td\u003e\n\u003c\/tr\u003e\n  \u003ctr\u003e\n\u003cth\u003eStorage\u003c\/th\u003e\n\u003ctd\u003eStore at-20°C for long term storage. Avoid freeze-thaw cycles.\u003c\/td\u003e\n\u003c\/tr\u003e\n  \u003ctr\u003e\n\u003cth\u003eApplication\u003c\/th\u003e\n\u003ctd\u003eWestern Blot (WB)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e\n\u003cdiv class=\"bhp-qc-badge\"\u003e✓ Pre-Formulated Quality Control Standard\u003c\/div\u003e\n\u003ch2\u003eUsage Notes\u003c\/h2\u003e\n\u003cp\u003eLoad 5–10 µL per lane (or as directed by the paired antibody datasheet). Centrifuge the vial briefly before opening. Divide into single-use aliquots after first use to minimise freeze-thaw degradation.\u003c\/p\u003e\n\u003ch2\u003eSafety \u0026amp; Handling\u003c\/h2\u003e\n\u003cdiv class=\"bhp-warning-box\"\u003e\u003cp\u003eSTRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.\u003c\/p\u003e\u003c\/div\u003e\n\u003c\/div\u003e","brand":"St John's Laboratory Ltd","offers":[{"title":"5 applications","offer_id":53326596931949,"sku":"STJ505505-5","price":425.73,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/product-no-image_3d0036bc-2521-4236-a518-497b2219c4a3.png?v=1778704892","url":"https:\/\/www.ebiohippo.com\/products\/dyrk2-positive-control-for-stj500809-antibody-stj505505-bhp15502029","provider":"BioHippo","version":"1.0","type":"link"}