{"product_id":"eca-109-cell-bhc11101544","title":"Eca-109 cell","description":"Eca-109 is a human esophageal squamous cell carcinoma (ESCC) cell line that is widely used for cancer research, particularly studies focusing on tumor progression, cell migration, and apoptosis. This cell line provides a representative model for esophageal cancer, which is a significant health concern with a high mortality rate due to aggressive progression and poor prognosis.\n\nIn research involving Eca-109 cells, several critical pathways have been studied. For instance, the modulation of autophagy has been shown to influence radiosensitivity. Inhibition of autophagy in Eca-109 cells, using agents such as 3-methyladenine (3-MA) or LY294002, has been demonstrated to enhance the cytotoxic effects of ionizing radiation by promoting apoptosis through mitochondrial pathways, including cytochrome c release and caspase activation. Furthermore, studies have highlighted the role of the EGFR\/ERK1\/2 signaling pathway in promoting migration and invasiveness of these cells, with findings that EGF stimulation increases aquaporin-8 (AQP8) expression, facilitating cell migration.\n\nAnother significant aspect of Eca-109 research is the exploration of therapeutic targets, such as galectin-3. Overexpression of this protein in Eca-109 cells has been associated with enhanced cell proliferation, migration, and invasion, while concurrently reducing apoptosis, indicating its potential as a molecular target for treatment.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101544\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950203466093,"sku":"305511","price":550.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Eca-109_20WaKo_20P1_2010x01_20270225_ch00_1920x1920_96af314a-f578-4f42-a8b3-0808296ad854.jpg?v=1769069015","url":"https:\/\/www.ebiohippo.com\/products\/eca-109-cell-bhc11101544","provider":"BioHippo","version":"1.0","type":"link"}