{"product_id":"efna1-antibody-ephrin-a1-bha17128190","title":"EFNA1 Antibody \/ Ephrin A1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e \u003cp\u003eEFNA1 Antibody \/ Ephrin A1 is an antibody targeting \u003cstrong\u003eEFNA1\u003c\/strong\u003e, raised in \u003cstrong\u003eMouse\u003c\/strong\u003e for protein detection and localization studies where these specifications are required.\u003c\/p\u003e \u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e \u003cul\u003e \u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e EFNA1.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eAntibody identity:\u003c\/strong\u003e Polyclonal (rabbit origin); Rabbit Ig.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eConjugate\/label:\u003c\/strong\u003e Unconjugated (affects detection chemistry and multiplex compatibility).\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Purified.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eSpecies reactivity:\u003c\/strong\u003e Human.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eListed applications:\u003c\/strong\u003e WB, IF (refer to on-page specifications for application-specific guidance).\u003c\/li\u003e \u003c\/ul\u003e  \u003ch2\u003eBiological background\u003c\/h2\u003e \u003cp\u003eEphrin A1 is a membrane-bound protein that interacts with Eph receptors on neighboring cells, initiating a cascade of signals that regulate cell behavior and movement. This interaction is essential for processes such as cell migration, tissue organization, and synaptic connectivity in the nervous system. Studies have shown that dysregulation of Ephrin A1 signaling can lead to aberrant cell growth, invasion, and metastasis in cancer cells, highlighting its importance in disease progression. One of the key features of Ephrin A1 is its ability to both attract and repel cells, depending on the context and concentration of the molecule. This dual role allows Ephrin A1 to fine-tune cell-cell interactions and ensure proper tissue patterning during development. In the brain, for example, Ephrin A1 guides axonal growth and synapse formation, shaping the intricate neural circuits that underlie cognitive functions. In addition to its role in development, Ephrin A1 has also been implicated in several disease processes. Aberrant expression of EFNA1 has been observed in various types of cancer, including breast, lung, and colon cancer, where it promotes tumor growth and invasion. In neurodegenerative disorders such as Alzheimer's disease, dysregulation of Ephrin A1 signaling disrupts synaptic connectivity and contributes to cognitive decline.\u003c\/p\u003e \u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eComparative expression profiling across cell types, tissues, or perturbations (e.g., drug treatment, genetic editing, or differentiation).\u003c\/li\u003e \u003cli\u003eSubcellular localization and trafficking studies, including co-localization with pathway markers in microscopy-based assays.\u003c\/li\u003e \u003cli\u003eIntegration of protein-level measurements with transcriptomics or proteomics to relate abundance to regulation and phenotype.\u003c\/li\u003e \u003c\/ul\u003e \u003ch2\u003eCommon research applications\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eWestern blotting: researchers commonly compare relative signal levels across conditions and use appropriate negative\/positive controls for interpretation.\u003c\/li\u003e \u003cli\u003eImmunofluorescence: researchers commonly compare relative signal levels across conditions and use appropriate negative\/positive controls for interpretation.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eInterpretation should account for antibody-dependent factors such as epitope accessibility, isoforms, and sample preparation differences across workflows.\u003c\/p\u003e \u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e \u003cul\u003e \u003cli\u003e\n\u003cstrong\u003eIsoforms and PTMs:\u003c\/strong\u003e many targets have multiple isoforms and post-translational modifications that can shift apparent signal or localization; interpret bands\/signals accordingly.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eEpitope context:\u003c\/strong\u003e binding can depend on protein conformation and sample processing; region information in the title\/immunogen can help anticipate what may be detected.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eSpecies differences:\u003c\/strong\u003e predicted or validated reactivity may vary by ortholog sequence and sample context; confirm in your model system.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eControl concepts:\u003c\/strong\u003e include negative controls (no-primary\/isotype), and where possible genetic controls (KO\/KD) or independent antibodies to strengthen conclusions.\u003c\/li\u003e \u003c\/ul\u003e \u003c!-- Sources (internal): - UniProtKB entry P20827 — UniProt — https:\/\/www.uniprot.org\/uniprotkb\/P20827 - Gene search: EFNA1 — NCBI Gene — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=EFNA1 - Ensembl search: EFNA1 — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=EFNA1 - PubMed search: EFNA1 antibody — PubMed — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=EFNA1+antibody - Reactome search: EFNA1 — Reactome — https:\/\/reactome.org\/content\/query?q=EFNA1 --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"In 1X PBS, pH 7.4, with 0.09% sodium azide and 50% glycerol \/ 0.1 ml","offer_id":53046409232749,"sku":"F55127-0.1ML","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_98afc0dd-f518-469b-8256-15520a9b9048.jpg?v=1772000492","url":"https:\/\/www.ebiohippo.com\/products\/efna1-antibody-ephrin-a1-bha17128190","provider":"BioHippo","version":"1.0","type":"link"}