{"product_id":"eif3h-antibody-eukaryotic-translation-initiation-factor-3-subunit-h-bha17135231","title":"EIF3H Antibody \/ Eukaryotic translation initiation factor 3 subunit H","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eEIF3H Antibody \/ Eukaryotic translation initiation factor 3 subunit H is a anti-EIF3H Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat. Reported localization: Cytoplasmic.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e EIF3H\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eEIF3H Antibody is used to study Eukaryotic translation initiation factor 3 subunit H, a core component of the eIF3 complex that orchestrates early steps of protein synthesis. As part of the multi-subunit eIF3 scaffold, Eukaryotic translation initiation factor 3 subunit H helps recruit the 40S ribosomal subunit, stabilizes the ternary complex, and promotes mRNA attachment and scanning to locate the start codon. By coordinating factor exchange and ribosome positioning, Eukaryotic translation initiation factor 3 subunit H contributes to the efficiency and selectivity of translation initiation, a checkpoint that powerfully shapes proteome output and cellular phenotype.\u003cbr\u003e\u003cbr\u003eFunctionally, Eukaryotic translation initiation factor 3 subunit H supports assembly of the 43S pre-initiation complex and helps maintain interactions with eIF4F-bound mRNAs. Perturbations in subunit stoichiometry can shift translation of specific mRNA cohorts, including transcripts with structured 5' UTRs or upstream open reading frames. In cancer models, amplification or overexpression of Eukaryotic translation initiation factor 3 subunit H correlates with elevated global translation and selective enhancement of growth-promoting messages. These properties make EIF3H Antibody valuable for charting how initiation control intersects with oncogenic signaling and stress adaptation.\u003cbr\u003e\u003cbr\u003eIn the laboratory, EIF3H Antibody enables detection of the native subunit in immunoblotting, monitors changes during serum starvation or mTOR pathway modulation, and supports co-immunoprecipitation to define interactions within the eIF3 complex. In immunofluorescence, the antibody reveals cytoplasmic distribution patterns that can be aligned with ribosomal markers or stress granule components. Researchers coupling EIF3H Antibody with polysome profiling, ribosome footprinting, or cap-binding assays can connect subunit abundance to translational throughput and transcript selectivity. Because initiation control influences cell growth, differentiation, and stress resilience, accurate measurement of this subunit helps interpret the translational state of diverse cell types.\u003cbr\u003e\u003cbr\u003eThe EIF3H Antibody from \u003cbr\u003e\u003cbr\u003eAs translation control emerges as a central driver of cell behavior, EIF3H Antibody provides a dependable means to quantify and localize a key eIF3 subunit, enabling researchers to connect molecular initiation events to system-level outcomes in development, cancer, and stress biology.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=EIF3H - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=EIF3H - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=EIF3H - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/EIF3H - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=EIF3H+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047286399341,"sku":"FY12328","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_6c2c664f-6b29-49f5-9815-c57679a55f3d.jpg?v=1782236999","url":"https:\/\/www.ebiohippo.com\/products\/eif3h-antibody-eukaryotic-translation-initiation-factor-3-subunit-h-bha17135231","provider":"BioHippo","version":"1.0","type":"link"}