{"product_id":"elf3-antibody-e74-like-factor-3-bha17135284","title":"ELF3 Antibody \/ E74-like factor 3","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eELF3 Antibody \/ E74-like factor 3 is a anti-ELF3 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunoprecipitation (IP), ELISA with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e ELF3\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IP, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eThe ELF3 antibody targets E74-like factor 3, a transcription factor encoded by the ELF3 gene that belongs to the ETS (E26 transformation-specific) family of DNA-binding proteins. E74-like factor 3 acts as an epithelial cell-specific transcriptional activator regulating genes involved in differentiation, barrier formation, and immune response. It binds ETS consensus sequences in gene promoters to modulate expression of epithelial keratins, claudins, and cytokines. The ELF3 antibody provides researchers with a powerful tool for exploring epithelial gene regulation, development, and cancer biology.\u003cbr\u003e\u003cbr\u003eE74-like factor 3 contains a highly conserved ETS DNA-binding domain and transcriptional activation region that interact with coactivators such as CBP\/p300. It is predominantly expressed in epithelial tissues including the gastrointestinal tract, lung, and mammary gland. The ELF3 antibody enables visualization of nuclear expression patterns in these tissues and supports mechanistic studies of epithelial-specific gene networks. In normal physiology, ELF3 regulates differentiation of epithelial cells by coordinating transcription of structural and signaling molecules necessary for tissue integrity.\u003cbr\u003e\u003cbr\u003eAberrant expression of ELF3 has been linked to carcinogenesis, especially in colorectal, breast, and bladder cancers. It may function as either a tumor suppressor or oncogene depending on context, influencing cell proliferation, invasion, and response to inflammatory cytokines. The ELF3 antibody allows quantitative and localization-based studies of this transcription factor in tumor samples, contributing to identification of prognostic markers and molecular subtypes. It also facilitates exploration of ELF3's interaction with beta-catenin and NF-?B pathways, which connect epithelial transcription programs to inflammation and cancer progression.\u003cbr\u003e\u003cbr\u003eIn immune regulation, E74-like factor 3 drives transcription of chemokines and adhesion molecules that coordinate epithelial immune responses to pathogens and injury. The ELF3 antibody supports studies into these processes, revealing how epithelial tissues integrate immune and barrier functions. Furthermore, ELF3 participates in developmental processes such as endoderm differentiation and organ morphogenesis by directing epithelial lineage specification. Its dysregulation in early development may contribute to congenital anomalies and tissue remodeling defects.\u003cbr\u003e\u003cbr\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=ELF3 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=ELF3 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=ELF3 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/ELF3 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=ELF3+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047287546221,"sku":"FY12381","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_6f86a795-0186-405d-a730-ce487ee60597.jpg?v=1782237006","url":"https:\/\/www.ebiohippo.com\/products\/elf3-antibody-e74-like-factor-3-bha17135284","provider":"BioHippo","version":"1.0","type":"link"}