{"product_id":"epoxomicin-bhb11900176","title":"Epoxomicin","description":"\u003cp\u003eEpoxomicin is a potent, cell-permeable, and selective inhibitor of the proteasome, originally isolated from an Actinomycetes strain for its antitumor properties. In neuroscience, Epoxomicin is widely used to study the ubiquitin-proteasome system (UPS), a critical pathway for protein degradation and cellular homeostasis in neurons. Dysfunction of the UPS is a hallmark of several neurodegenerative diseases, including Alzheimer’s, Parkinson’s, and Huntington’s disease, where misfolded or aggregated proteins accumulate. Epoxomicin inhibits the chymotrypsin-like, trypsin-like, and PGPH activities of the proteasome, making it a valuable tool for dissecting proteostasis mechanisms. It also indirectly activates autophagy, a compensatory degradation pathway, by blocking UPS function. Additionally, Epoxomicin suppresses NF-κB activation and inflammation, further supporting its use in neuroinflammatory models. Its dual role in modulating protein clearance and inflammatory signaling makes it highly relevant in neurodegenerative disease research.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"100 ug","offer_id":53040946741613,"sku":"SIH-388-100UG","price":223.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-388_Epoxomicin_Chemical_Structure.png?v=1771837644","url":"https:\/\/www.ebiohippo.com\/products\/epoxomicin-bhb11900176","provider":"BioHippo","version":"1.0","type":"link"}