{"product_id":"estrogen-receptor-antibody-beta-bha17104019","title":"Estrogen Receptor Antibody (beta)","description":"\u003ch2\u003eOverview\u003c\/h2\u003e \u003cp\u003eEstrogen Receptor antibody supplied as a antigen affinity purified reagent for WB in Human samples. This product is a polyclonal (rabbit origin) antibody (host: Rabbit; isotype: Rabbit IgG) intended for research use only.\u003c\/p\u003e \u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e \u003cul\u003e   \u003cli\u003e\n\u003cstrong\u003eAntibody identity:\u003c\/strong\u003e Polyclonal (rabbit origin); host Rabbit; isotype Rabbit IgG.\u003c\/li\u003e   \u003cli\u003e\n\u003cstrong\u003eFormat and purification:\u003c\/strong\u003e format: Antigen affinity purified; purity: Antigen affinity.\u003c\/li\u003e   \u003cli\u003e\n\u003cstrong\u003eSpecies reactivity (reported):\u003c\/strong\u003e Human.\u003c\/li\u003e   \u003cli\u003e\n\u003cstrong\u003eApplications (listed):\u003c\/strong\u003e WB.\u003c\/li\u003e   \u003cli\u003e\n\u003cstrong\u003eImmunogen \/ epitope context:\u003c\/strong\u003e An amino acid sequence from the N-terminus of human Estrogen Receptor beta (HGSIYIPSSYVDSHHEYPAMTFYS) was used as the immunogen for this Estrogen Receptor antibody..\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eThese attributes help you align the antibody with the biological question (target state, sample type, and readout) while keeping interpretation grounded in appropriate controls.\u003c\/p\u003e \u003ch2\u003eBiological background\u003c\/h2\u003e \u003cp\u003eEstrogen Receptor is the intended antigen for this primary antibody. Reported biological context includes: Estrogen receptor-beta, referred to as ESR2 or ER\u003cfont face=\"symbol\"\u003eb\u003c\/font\u003e, is a member of the superfamily of nuclear receptors which can transduce extracellular signals into transcriptional responses. This gene is mapped to 14q and comprises 8 exons spanning approximately 40 kb.\u003c\/p\u003e \u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e \u003cul\u003e   \u003cli\u003eSpatial and single-cell approaches: imaging-based and cytometry workflows increasingly quantify heterogeneity and relocalization rather than only bulk abundance.\u003c\/li\u003e   \u003cli\u003eInteraction-centric biology: IP-based enrichment and proteomics are widely used to define complexes, binding partners, and context-specific interactomes.\u003c\/li\u003e \u003c\/ul\u003e \u003ch2\u003eCommon research applications\u003c\/h2\u003e \u003cul\u003e   \u003cli\u003eWestern blot (WB): compare relative abundance\/isoform patterns across conditions and sample types; band shifts may reflect processing or post-translational modification.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eAcross these readouts, differences in signal intensity, localization, or complex enrichment are typically interpreted alongside sample-matched controls and independent evidence to distinguish regulation from technical variation.\u003c\/p\u003e \u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e \u003cul\u003e   \u003cli\u003eIsoforms, cleavage products, or post-translational modifications can alter apparent molecular weight and subcellular distribution; interpret bands and staining patterns in the context of expected biology and sample preparation.\u003c\/li\u003e   \u003cli\u003eSpecies differences and epitope conservation may affect binding; use matched positive controls and orthogonal evidence when comparing across organisms.\u003c\/li\u003e   \u003cli\u003eControl concepts: include appropriate isotype and secondary-only controls (for imaging), and consider genetic perturbations (knockout\/knockdown\/overexpression) or independent antibodies targeting distinct epitopes to strengthen conclusions.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eEpitope context is defined by the immunogen description; when available, align this with known domains, PTM sites, or family homology to anticipate potential cross-reactivity patterns. As a polyclonal antibody, recognition spans multiple epitopes, which can improve detection across conformations but may broaden background depending on sample context.\u003c\/p\u003e \u003c!-- Sources (internal): - UniProtKB entry (Q92731) — UniProt Consortium — https:\/\/www.uniprot.org\/uniprotkb\/Q92731\/entry - NCBI Gene search (Estrogen Receptor) — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=Estrogen+Receptor - Ensembl search (Estrogen Receptor) — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=Estrogen+Receptor - PubMed search (Estrogen Receptor) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Estrogen+Receptor - Reactome pathway search (Estrogen Receptor) — Reactome — https:\/\/reactome.org\/content\/query?q=Estrogen+Receptor --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.5mg\/ml if reconstituted with 0.2ml sterile DI water \/ 100 ug","offer_id":53043257639277,"sku":"R30294","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_83b1633d-b917-4941-ad81-2a2be9047964.jpg?v=1771934473","url":"https:\/\/www.ebiohippo.com\/products\/estrogen-receptor-antibody-beta-bha17104019","provider":"BioHippo","version":"1.0","type":"link"}