{"product_id":"eurl-antibody-expressed-in-undifferentiated-retina-and-lens-c21orf91-bha17136084","title":"EURL Antibody \/ Expressed in undifferentiated retina and lens \/ C21orf91","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eEURL Antibody \/ Expressed in undifferentiated retina and lens \/ C21orf91 is a anti-EURL Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e EURL\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eEURL antibody detects C21orf91 protein, also known as EURL (expressed in undifferentiated retina and lens), a cytoplasmic regulator of neurogenesis and neuronal differentiation. The UniProt recommended name is C21orf91 protein (EURL). This protein contributes to neurodevelopment by modulating the balance between neural progenitor proliferation and differentiation.\u003cbr\u003e\u003cbr\u003eFunctionally, EURL antibody identifies a 250-amino-acid cytoplasmic protein that interacts with components of the microtubule and actin cytoskeleton to influence cell shape and division. EURL expression is enriched in neural precursor cells, where it controls neuronal lineage specification and cortical development. It also supports early lens and retinal formation during embryogenesis.\u003cbr\u003e\u003cbr\u003eThe EURL gene is located on chromosome 21q22.12, within the Down syndrome critical region. Its expression in the developing brain suggests a role in cortical layering and synaptic maturation. EURL may also contribute to dosage-sensitive developmental pathways affected by trisomy 21.\u003cbr\u003e\u003cbr\u003ePathologically, altered EURL expression has been associated with neurodevelopmental delay and Down syndrome-related brain abnormalities. Dysregulation affects neuronal migration and axon guidance, leading to impaired neural circuit formation. Research using EURL antibody supports studies in brain development, neurogenetics, and cytoskeletal dynamics.\u003cbr\u003e\u003cbr\u003eEURL antibody is validated for western blotting, immunohistochemistry, and immunofluorescence to detect neural differentiation markers. \u003cbr\u003e\u003cbr\u003eStructurally, C21orf91 protein contains conserved helical motifs that mediate cytoskeletal binding and spatial organization within developing neurons. This antibody enables analysis of EURL's role in neuronal specification and brain morphogenesis.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=EURL - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=EURL - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=EURL - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/EURL - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=EURL+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047318348141,"sku":"FY13182","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_2ed4ecdb-3025-4169-a8ce-813867010991.jpg?v=1782237087","url":"https:\/\/www.ebiohippo.com\/products\/eurl-antibody-expressed-in-undifferentiated-retina-and-lens-c21orf91-bha17136084","provider":"BioHippo","version":"1.0","type":"link"}