{"product_id":"ex-527-bhb11900141","title":"EX-527","description":"\u003cp\u003eEX-527 is a potent and selective SIRT1 inhibitor (IC₅₀ = 98 nM) that does not affect other sirtuins or HDACs. It increases p53 acetylation following DNA damage and is fully cell permeable.\u003c\/p\u003e \u003cp\u003eIn neuroscience, EX-527 has been shown to promote neuronal differentiation from pluripotent stem cells and modulate neurogenesis-related transcription factors. Its ability to influence cell fate decisions and epigenetic plasticity makes it a valuable probe for studying neurodevelopment, cellular reprogramming, and SIRT1-linked pathways in neurodegenerative disease models.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"5 mg","offer_id":53040944546157,"sku":"SIH-353-5MG","price":101.0,"currency_code":"USD","in_stock":true},{"title":"25 mg","offer_id":53040962601325,"sku":"SIH-353-25MG","price":401.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-353_EX-527_Chemical_Structure.png?v=1771837627","url":"https:\/\/www.ebiohippo.com\/products\/ex-527-bhb11900141","provider":"BioHippo","version":"1.0","type":"link"}