{"product_id":"fbxo7-antibody-f-box-only-protein-7-bha17136039","title":"FBXO7 Antibody \/ F-box only protein 7","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eFBXO7 Antibody \/ F-box only protein 7 is a anti-FBXO7 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Flow cytometry (FACS), ELISA with listed reactivity in Human, Rat. Reported localization: Nuclear, cytoplasmic.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e FBXO7\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, ICC\/IF, IP, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eFBXO7 antibody detects F-box only protein 7, an E3 ubiquitin ligase component that regulates protein degradation, cell cycle progression, and mitochondrial quality control. The UniProt recommended name is F-box only protein 7 (FBXO7). This protein belongs to the F-box family, which mediates substrate recognition within SCF (SKP1-CUL1-F-box) ubiquitin ligase complexes, promoting selective proteasomal degradation of target proteins.\u003cbr\u003e\u003cbr\u003eFunctionally, FBXO7 antibody identifies a 522-amino-acid cytoplasmic and nuclear protein containing an F-box domain for SCF complex binding and a proline-rich region that mediates protein-protein interactions. FBXO7 participates in cell cycle regulation by targeting cell cycle inhibitors for ubiquitination. It also plays a role in mitophagy by interacting with PINK1 and Parkin to promote the clearance of damaged mitochondria, maintaining neuronal and muscular health.\u003cbr\u003e\u003cbr\u003eThe FBXO7 gene is located on chromosome 22q12.3 and is broadly expressed, with high levels in brain, skeletal muscle, and lymphoid tissues. Its cellular distribution reflects multifunctional roles in ubiquitin-mediated proteolysis, cytoskeletal organization, and signal transduction.\u003cbr\u003e\u003cbr\u003ePathologically, mutations in FBXO7 are associated with Parkinsonian-pyramidal syndrome (PARK15), a neurodegenerative disorder combining parkinsonism with upper motor neuron dysfunction. Loss of FBXO7 disrupts mitophagy, leading to mitochondrial dysfunction and neurodegeneration. Research using FBXO7 antibody supports studies in protein degradation, neurobiology, and mitochondrial homeostasis.\u003cbr\u003e\u003cbr\u003eFBXO7 antibody is validated for western blotting, immunofluorescence, and immunohistochemistry to detect F-box proteins and ubiquitination regulators. \u003cbr\u003e\u003cbr\u003eStructurally, F-box only protein 7 contains an F-box domain for SKP1 binding, coiled-coil regions for dimerization, and a ubiquitin-like domain that facilitates substrate recruitment. This antibody enables detailed characterization of FBXO7's function in E3 ligase activity and mitochondrial quality control.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=FBXO7 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=FBXO7 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=FBXO7 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/FBXO7 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=FBXO7+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047313236333,"sku":"FY13137","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_1e9dd668-6fa3-4010-8a97-ab16b5470093.jpg?v=1782237089","url":"https:\/\/www.ebiohippo.com\/products\/fbxo7-antibody-f-box-only-protein-7-bha17136039","provider":"BioHippo","version":"1.0","type":"link"}