{"product_id":"fcrl4-antibody-fc-receptor-like-protein-4-bha17128171","title":"FCRL4 Antibody \/ Fc receptor-like protein 4","description":"\u003ch2\u003eOverview\u003c\/h2\u003e \u003cp\u003eFCRL4 Antibody \/ Fc receptor-like protein 4 is an antibody targeting \u003cstrong\u003eFCRL4\u003c\/strong\u003e, raised in \u003cstrong\u003eRabbit\u003c\/strong\u003e for protein detection and localization studies where these specifications are required.\u003c\/p\u003e \u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e \u003cul\u003e \u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e FCRL4.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eAntibody identity:\u003c\/strong\u003e Polyclonal (rabbit origin); Rabbit Ig.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eConjugate\/label:\u003c\/strong\u003e Unconjugated (affects detection chemistry and multiplex compatibility).\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Purified.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eSpecies reactivity:\u003c\/strong\u003e Human.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eListed applications:\u003c\/strong\u003e WB, FACS (refer to on-page specifications for application-specific guidance).\u003c\/li\u003e \u003c\/ul\u003e  \u003ch2\u003eBiological background\u003c\/h2\u003e \u003cp\u003eFc receptor-like proteins (FCRLs) are a family of receptors that resemble Fc receptors, which are usually found on immune cells and are involved in recognizing and binding to antibodies. FCRL4, in particular, has been shown to be expressed on B cells and T cells, suggesting its involvement in immune regulation. One of the key functions of FCRL4 is its ability to modulate the activation and signaling pathways of immune cells. Studies have indicated that FCRL4 may play a role in regulating B cell responses, including antibody production and immune cell activation. Additionally, FCRL4 has been linked to autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus, highlighting its importance in immune dysregulation.\u003c\/p\u003e \u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eComparative expression profiling across cell types, tissues, or perturbations (e.g., drug treatment, genetic editing, or differentiation).\u003c\/li\u003e \u003cli\u003eSubcellular localization and trafficking studies, including co-localization with pathway markers in microscopy-based assays.\u003c\/li\u003e \u003cli\u003eIntegration of protein-level measurements with transcriptomics or proteomics to relate abundance to regulation and phenotype.\u003c\/li\u003e \u003c\/ul\u003e \u003ch2\u003eCommon research applications\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eWestern blotting: researchers commonly compare relative signal levels across conditions and use appropriate negative\/positive controls for interpretation.\u003c\/li\u003e \u003cli\u003eFlow cytometry: researchers commonly compare relative signal levels across conditions and use appropriate negative\/positive controls for interpretation.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eInterpretation should account for antibody-dependent factors such as epitope accessibility, isoforms, and sample preparation differences across workflows.\u003c\/p\u003e \u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e \u003cul\u003e \u003cli\u003e\n\u003cstrong\u003eIsoforms and PTMs:\u003c\/strong\u003e many targets have multiple isoforms and post-translational modifications that can shift apparent signal or localization; interpret bands\/signals accordingly.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eEpitope context:\u003c\/strong\u003e binding can depend on protein conformation and sample processing; region information in the title\/immunogen can help anticipate what may be detected.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eSpecies differences:\u003c\/strong\u003e predicted or validated reactivity may vary by ortholog sequence and sample context; confirm in your model system.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eControl concepts:\u003c\/strong\u003e include negative controls (no-primary\/isotype), and where possible genetic controls (KO\/KD) or independent antibodies to strengthen conclusions.\u003c\/li\u003e \u003c\/ul\u003e \u003c!-- Sources (internal): - UniProtKB entry Q96PJ5 — UniProt — https:\/\/www.uniprot.org\/uniprotkb\/Q96PJ5 - Gene search: FCRL4 — NCBI Gene — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=FCRL4 - Ensembl search: FCRL4 — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=FCRL4 - PubMed search: FCRL4 antibody — PubMed — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=FCRL4+antibody - Reactome search: FCRL4 — Reactome — https:\/\/reactome.org\/content\/query?q=FCRL4 --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"In 1X PBS, pH 7.4, with 0.09% sodium azide \/ 0.08 ml","offer_id":53046411559277,"sku":"F55108-0.08ML","price":205.0,"currency_code":"USD","in_stock":true},{"title":"In 1X PBS, pH 7.4, with 0.09% sodium azide \/ 0.4 ml","offer_id":53046470967661,"sku":"F55108-0.4ML","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_4b01ff6a-bee9-4315-95d2-646d894506ff.jpg?v=1772000495","url":"https:\/\/www.ebiohippo.com\/products\/fcrl4-antibody-fc-receptor-like-protein-4-bha17128171","provider":"BioHippo","version":"1.0","type":"link"}