{"product_id":"fetub-antibody-fetuin-b-bha17135723","title":"FETUB Antibody \/ Fetuin B","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eFETUB Antibody \/ Fetuin B is a anti-FETUB Rabbit antibody Recombinant Rabbit Monoclonal clone 31F67 supplied in Liquid format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC) with listed reactivity in Human, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e FETUB\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 31F67, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eFETUB antibody detects FETUIN B, encoded by the FETUB gene. Alternate names include FETUB protein, Fetuin 2, and Fetuin like glycoprotein. FETUIN B is a secreted plasma glycoprotein belonging to the cystatin superfamily of cysteine protease inhibitors. Although structurally related to FETUIN A, FETUIN B has distinct biological functions. It is primarily expressed in the liver and secreted into the bloodstream, where it regulates protease activity, fertilization, and metabolic signaling. FETUB contains cystatin like domains that inhibit specific proteases, contributing to extracellular proteolysis control.\u003cbr\u003e\u003cbr\u003eFETUB antibody is widely applied in metabolism, reproduction, and protease biology. A key role of FETUIN B is in fertilization, where it inhibits the protease ovastacin, preventing premature hardening of the zona pellucida and ensuring successful sperm penetration. Loss of FETUB function results in female infertility due to zona pellucida hardening defects. By detecting FETUB, researchers can explore how this protein supports reproductive biology and fertility.\u003cbr\u003e\u003cbr\u003eBeyond reproduction, FETUIN B regulates extracellular proteases involved in tissue remodeling, inflammation, and fibrosis. Studies in liver biology reveal that altered FETUB expression contributes to chronic liver disease and cancer. Because it is secreted into blood, FETUB is measurable in plasma, making it a potential biomarker for disease diagnosis and prognosis.\u003cbr\u003e\u003cbr\u003eApplications of FETUB antibody include western blotting, immunohistochemistry, immunofluorescence, and ELISA. Western blotting detects FETUB in serum and liver extracts, immunohistochemistry maps expression in hepatocytes and ovarian tissues, and immunofluorescence highlights its localization in secretory pathways. ELISA enables quantification of circulating FETUB, linking research findings to clinical diagnostics. These methods provide powerful approaches for studying this multifunctional glycoprotein.\u003cbr\u003e\u003cbr\u003eAltered FETUB expression has been implicated in metabolic disease, including obesity, insulin resistance, and type 2 diabetes. Elevated circulating levels may reflect metabolic stress and inflammation. In oncology, FETUB has been reported as a prognostic biomarker in hepatocellular carcinoma and other cancers. By applying FETUB antibody, scientists can study its dual roles in fertility and systemic disease.\u003cbr\u003e\u003cbr\u003eFETUB is also a subject of evolutionary biology research. While related to FETUIN A, its divergence highlights specialized reproductive functions. This specialization underscores the importance of studying FETUB independently of FETUIN A. Antibody based detection allows researchers to dissect these evolutionary adaptations.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=FETUB - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=FETUB - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=FETUB - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/FETUB - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=FETUB+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047303078253,"sku":"FY12821","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_5632d1b8-364e-4a16-b025-cfad8f584649.jpg?v=1772019348","url":"https:\/\/www.ebiohippo.com\/products\/fetub-antibody-fetuin-b-bha17135723","provider":"BioHippo","version":"1.0","type":"link"}