{"product_id":"fgl1-antibody-fibrinogen-like-protein-1-bha17135560","title":"FGL1 Antibody \/ Fibrinogen-like protein 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eFGL1 Antibody \/ Fibrinogen-like protein 1 is a anti-FGL1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC) with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e FGL1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eFGL1 antibody detects Fibrinogen-like protein 1, a hepatocyte-derived secreted glycoprotein that plays dual roles in liver regeneration and immune regulation. FGL1 is structurally similar to fibrinogen beta and gamma chains but functions as an immune checkpoint ligand for LAG-3, contributing to T-cell inhibition and immune tolerance. The FGL1 antibody is widely used in immunology, oncology, and hepatic biology research to study immune evasion, regeneration, and tumor immunotherapy.\u003cbr\u003e\u003cbr\u003eFGL1 is encoded by the FGL1 gene located on human chromosome 8p22. The protein is approximately 312 amino acids long and contains a fibrinogen-like domain that mediates binding to the lymphocyte-activation gene 3 (LAG-3) receptor. FGL1 is predominantly expressed in the liver but can also be produced by tumor cells and tissues under regenerative or inflammatory conditions. It is secreted into plasma, acting in both paracrine and systemic signaling.\u003cbr\u003e\u003cbr\u003eThe FGL1 antibody detects a 35 kilodalton protein by western blot and shows cytoplasmic and secretory vesicle localization under immunostaining. In normal physiology, FGL1 supports hepatocyte proliferation and tissue regeneration following liver injury by activating ERK and STAT3 pathways. In the immune system, FGL1 serves as a non-MHC ligand for LAG-3, suppressing effector T-cell activation and cytokine release, thereby promoting immune tolerance.\u003cbr\u003e\u003cbr\u003eIn cancer, FGL1 is frequently upregulated and mediates resistance to immunotherapies targeting the PD-1\/PD-L1 axis. High expression correlates with poor prognosis in hepatocellular carcinoma, lung cancer, and melanoma. Neutralization of FGL1 enhances antitumor immunity, making it an emerging therapeutic target for combination checkpoint blockade. Beyond oncology, altered FGL1 levels are associated with metabolic disorders and liver fibrosis.\u003cbr\u003e\u003cbr\u003eAs a multifunctional factor bridging liver regeneration and immune suppression, FGL1 provides critical insights into tissue repair and immune escape.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=FGL1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=FGL1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=FGL1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/FGL1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=FGL1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047295803757,"sku":"FY12657","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_af599913-d4eb-4f99-9bc3-18aa3644d2e3.jpg?v=1782237032","url":"https:\/\/www.ebiohippo.com\/products\/fgl1-antibody-fibrinogen-like-protein-1-bha17135560","provider":"BioHippo","version":"1.0","type":"link"}