{"product_id":"foxm1-antibody-forkhead-box-protein-m1-bha17135733","title":"FOXM1 Antibody \/ Forkhead box protein M1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eFOXM1 Antibody \/ Forkhead box protein M1 is a anti-FOXM1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP) with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e FOXM1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, ELISA, IP\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eFOXM1 antibody detects Forkhead box protein M1, a transcription factor that regulates cell cycle progression, DNA replication, and mitotic gene expression. Encoded by the FOXM1 gene on chromosome 12p13.33, this nuclear protein belongs to the Forkhead family of transcription factors, characterized by a conserved winged-helix DNA-binding domain. FOXM1 functions as a key regulator of cell proliferation by activating genes required for G1\/S and G2\/M phase transitions, including cyclins, PLK1, and CDC25B.\u003cbr\u003e\u003cbr\u003eFOXM1 localizes to the nucleus during interphase and associates with condensed chromosomes during mitosis. Its activity is controlled by phosphorylation through CDKs and PLK1, which modulate DNA-binding and transcriptional activation. FOXM1 also contributes to chromatin remodeling and genomic stability by facilitating DNA repair and replication stress responses. It serves as an essential factor in tissue regeneration, stem cell renewal, and oncogenic transformation.\u003cbr\u003e\u003cbr\u003eThe FOXM1 antibody is widely used in cancer, developmental, and cell cycle research to investigate proliferation control and transcriptional regulation. Western blot analysis detects a 90 kilodalton band corresponding to FOXM1, while immunofluorescence shows strong nuclear staining in proliferating cells. This antibody enables assessment of mitotic activity and transcriptional control mechanisms in both normal and cancerous tissues.\u003cbr\u003e\u003cbr\u003eOverexpression of FOXM1 is a hallmark of many human cancers, where it promotes tumor growth, angiogenesis, and metastasis through activation of cell cycle and invasion-related genes. Its inhibition is being explored as a therapeutic strategy for targeting rapidly dividing cells. The FOXM1 antibody provides a reliable tool for studying transcriptional regulation of proliferation and tumorigenesis.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=FOXM1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=FOXM1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=FOXM1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/FOXM1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=FOXM1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047302914413,"sku":"FY12831","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_9bc7f488-4dc5-4a4e-8d45-ae910d72a4e2.jpg?v=1782237052","url":"https:\/\/www.ebiohippo.com\/products\/foxm1-antibody-forkhead-box-protein-m1-bha17135733","provider":"BioHippo","version":"1.0","type":"link"}