{"product_id":"fzr1-antibody-bha17102415","title":"FZR1 Antibody","description":"\u003cp\u003eFizzy related protein 1 is a key regulator of ligase activity of the anaphase promoting complex\/cyclosome (APC\/C), which confers substrate specificity upon the complex. Associates with the APC\/C in late mitosis, in replacement of CDC20, and activates the APC\/C during anaphase and telophase. The APC\/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1\/S transition FZR1 is phosphorylated, leading to its dissociation from the APC\/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC\/C leads to the ubiquitination of PLK1, preventing entry into mitosis.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Purified\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"NSJ Bioreagents","offers":[{"title":"In 1X PBS, pH 7.4, with 0.09% sodium azide \/ 0.05 ml","offer_id":53042930811245,"sku":"F53804-0.05ML","price":205.0,"currency_code":"USD","in_stock":true},{"title":"In 1X PBS, pH 7.4, with 0.09% sodium azide \/ 0.2 ml","offer_id":53043012370797,"sku":"F53804-0.2ML","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_77f33f9a-bf38-4b31-94a1-25000ffd8bda.jpg?v=1771924016","url":"https:\/\/www.ebiohippo.com\/products\/fzr1-antibody-bha17102415","provider":"BioHippo","version":"1.0","type":"link"}