{"product_id":"gabaa-receptor-beta-3-antibody-bha11903146","title":"GABAA Receptor Beta 3 Antibody","description":"\u003cp\u003eThe GABA-A receptor beta 3 subunit (GABRB3) is a vital component of the GABA-A receptor complex, the primary class of fast-acting ligand-gated ion channels responsible for inhibitory neurotransmission in the brain. These receptors are essential for maintaining the balance between neuronal excitation and inhibition, a process critical for normal brain function and network stability.\u003c\/p\u003e\n\n\u003cp\u003eGABRB3 is widely expressed in the central nervous system and plays a key role in shaping synaptic and extrasynaptic inhibitory currents. Genetic and functional alterations in GABRB3 have been linked to a range of neurological and neurodevelopmental disorders, including epilepsy, autism spectrum disorders, and Angelman syndrome. More recently, GABRB3 has emerged as a candidate of interest in neurodegenerative disease research, where disrupted GABAergic signaling contributes to cognitive decline, synaptic dysfunction, and neuronal vulnerability.\u003c\/p\u003e\n\n\u003cp\u003eIn conditions such as Alzheimer’s disease, reduced GABRB3 expression may impair inhibitory tone, leading to network hyperexcitability and excitotoxicity—hallmarks of disease progression. As a result, GABRB3 is being explored as both a biomarker and a therapeutic target for restoring inhibitory balance and protecting against neurodegeneration.\u003c\/p\u003e\n\n\u003cp\u003eUnderstanding the role of GABRB3 in inhibitory signaling pathways offers valuable insights into the molecular mechanisms underlying neurodegenerative diseases and supports the development of targeted interventions aimed at preserving cognitive function.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"100 ug \/ Unconjugated","offer_id":53040789750125,"sku":"SMC-339D","price":337.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 390","offer_id":53040824418669,"sku":"SMC-339D-A390","price":392.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 488","offer_id":53040824451437,"sku":"SMC-339D-A488","price":391.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 594","offer_id":53040824484205,"sku":"SMC-339D-A594","price":391.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ APC","offer_id":53040824516973,"sku":"SMC-339D-APC","price":390.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ BI","offer_id":53040824549741,"sku":"SMC-339D-BI","price":386.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ FITC","offer_id":53040824582509,"sku":"SMC-339D-FITC","price":381.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ HRP","offer_id":53040824615277,"sku":"SMC-339D-HRP","price":377.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ PCP","offer_id":53040824648045,"sku":"SMC-339D-PCP","price":390.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ RPE","offer_id":53040824680813,"sku":"SMC-339D-RPE","price":388.0,"currency_code":"USD","in_stock":true},{"title":"12 ug \/ Unconjugated","offer_id":53040824713581,"sku":"SMC-339S","price":45.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SMC-339_GABA-A-Receptor-Beta-3_Antibody_N87-25_ICC-IF_Human_Neuroblastoma-cells-SH-SY5Y-Composite-1.png?v=1771832139","url":"https:\/\/www.ebiohippo.com\/products\/gabaa-receptor-beta-3-antibody-bha11903146","provider":"BioHippo","version":"1.0","type":"link"}