{"product_id":"gabarap-antibody-bha11908261","title":"GABARAP Antibody","description":"\u003cp\u003eGamma-aminobutyric acid receptor-associated protein (GABARAP) is a multifunctional protein originally identified for its role in clustering and trafficking GABA-A receptors, the primary mediators of fast inhibitory neurotransmission in the brain. By anchoring these ligand-gated chloride channels to the cytoskeleton, GABARAP ensures proper receptor localization at synaptic membranes, thereby maintaining inhibitory synaptic strength and neuronal network stability.\u003c\/p\u003e\n\n\u003cp\u003eBeyond its role in receptor trafficking, GABARAP is now recognized as a critical component of the autophagy machinery. It belongs to the Atg8 family of proteins and participates in autophagosome formation, cargo recognition, and lysosomal degradation—processes essential for cellular homeostasis and neuroprotection.\u003c\/p\u003e\n\n\u003cp\u003eDysregulation of GABARAP has been implicated in several neurodegenerative diseases, including Alzheimer’s, Parkinson’s, and Huntington’s disease. Impaired GABARAP-mediated autophagy may lead to the accumulation of toxic protein aggregates and dysfunctional organelles, contributing to neuronal death and disease progression. Additionally, altered GABA-A receptor trafficking due to GABARAP dysfunction can disrupt inhibitory signaling, further exacerbating excitotoxicity and synaptic imbalance.\u003c\/p\u003e\n\n\u003cp\u003eGiven its dual role in synaptic regulation and autophagy, GABARAP is emerging as a promising molecular target in neurodegeneration research. Understanding its mechanisms may offer new therapeutic strategies for restoring cellular homeostasis and preserving neural function in aging and disease.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"100 ug \/ Unconjugated","offer_id":53040794141037,"sku":"SPC-620D","price":338.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 390","offer_id":53040879599981,"sku":"SPC-620D-A390","price":393.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 488","offer_id":53040879632749,"sku":"SPC-620D-A488","price":392.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 594","offer_id":53040879665517,"sku":"SPC-620D-A594","price":392.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ APC","offer_id":53040879698285,"sku":"SPC-620D-APC","price":391.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ BI","offer_id":53040879731053,"sku":"SPC-620D-BI","price":388.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ FITC","offer_id":53040879763821,"sku":"SPC-620D-FITC","price":383.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ HRP","offer_id":53040879796589,"sku":"SPC-620D-HRP","price":378.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ PCP","offer_id":53040879829357,"sku":"SPC-620D-PCP","price":391.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ RPE","offer_id":53040879862125,"sku":"SPC-620D-RPE","price":389.0,"currency_code":"USD","in_stock":true},{"title":"12 ug \/ Unconjugated","offer_id":53040879894893,"sku":"SPC-620S","price":45.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SPC-620-GABARAP-Antibody-ICC-IF-Human-Neuroblastoma-cell-line-SK-N-BE-60X-Composite-1.png?v=1771832163","url":"https:\/\/www.ebiohippo.com\/products\/gabarap-antibody-bha11908261","provider":"BioHippo","version":"1.0","type":"link"}