{"product_id":"gabbr2-antibody-gaba-b-receptor-2-bha17135342","title":"GABBR2 Antibody \/ GABA-B receptor 2","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eGABBR2 Antibody \/ GABA-B receptor 2 is a anti-GABBR2 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), ELISA with listed reactivity in Human, Mouse, Rat. Reported localization: Cell membrane, cytoplasm.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e GABBR2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eGABBR2 antibody recognizes gamma-aminobutyric acid type B receptor subunit 2, a critical component of the GABA-B receptor complex that mediates inhibitory neurotransmission in the central nervous system. The GABA-B receptor is a G-protein-coupled receptor (GPCR) that functions as an obligate heterodimer composed of GABBR1 and GABBR2 subunits. While GABBR1 primarily binds the neurotransmitter GABA, GABBR2 is essential for G-protein coupling and signal transduction. Together, they regulate synaptic transmission, neuronal excitability, and plasticity by modulating calcium and potassium channels. The GABBR2 antibody is widely used in neuroscience research to study receptor distribution, intracellular trafficking, and synaptic physiology, as well as in models of epilepsy, addiction, and neurodegeneration.\u003cbr\u003e\u003cbr\u003eGABBR2 is a transmembrane protein encoded by the GABBR2 gene, located on human chromosome 9q22.33. It contains a large extracellular Venus flytrap domain, a seven-transmembrane GPCR domain, and a long cytoplasmic tail involved in receptor assembly and signaling. The interaction of GABBR2 with GABBR1 is required for proper receptor localization at the cell surface. Dysregulation or mutations in GABBR2 have been associated with neurodevelopmental disorders, such as Rett-like syndrome and epileptic encephalopathy, emphasizing its importance in synaptic regulation. Experimental models have shown that altered GABA-B receptor function contributes to impaired inhibitory signaling and enhanced neuronal hyperexcitability.\u003cbr\u003e\u003cbr\u003eThe GABBR2 antibody is particularly valuable in immunohistochemistry for mapping GABA-B receptor expression across different brain regions, including the hippocampus, cortex, cerebellum, and spinal cord. Western blot analysis using this antibody often reveals bands around 100-110 kDa, corresponding to the mature receptor subunit. It is also useful in co-immunoprecipitation studies to confirm receptor dimerization with GABBR1 and interaction with downstream signaling molecules such as G-proteins and adenylate cyclases. Because of its high specificity and reproducibility, this antibody has become a standard reagent for characterizing the molecular and cellular mechanisms of inhibitory neurotransmission. \u003cbr\u003e\u003cbr\u003eResearch into GABBR2 continues to illuminate its roles beyond classical neurotransmission. Studies have linked GABA-B receptor signaling to cognitive flexibility, mood regulation, and drug dependence. Pharmacological modulation of this receptor has shown promise in treating anxiety, spasticity, and addiction disorders. The availability of a reliable GABBR2 antibody facilitates continued exploration into the receptor's signaling mechanisms, post-translational modifications, and potential therapeutic targets in neurological and psychiatric diseases.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=GABBR2 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=GABBR2 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=GABBR2 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/GABBR2 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=GABBR2+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047285514605,"sku":"FY12439","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_eb0ff89b-b652-42c3-a6d5-d8336f0c3aad.jpg?v=1782237005","url":"https:\/\/www.ebiohippo.com\/products\/gabbr2-antibody-gaba-b-receptor-2-bha17135342","provider":"BioHippo","version":"1.0","type":"link"}