{"product_id":"galnt2-antibody-polypeptide-n-acetylgalactosaminyltransferase-2-bha17135860","title":"GALNT2 Antibody \/ Polypeptide N-acetylgalactosaminyltransferase 2","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eGALNT2 Antibody \/ Polypeptide N-acetylgalactosaminyltransferase 2 is a anti-GALNT2 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunoprecipitation (IP), ELISA with listed reactivity in Human, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e GALNT2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IP, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eGALNT2 antibody detects Polypeptide N-acetylgalactosaminyltransferase 2, an enzyme that initiates mucin-type O-linked glycosylation by transferring N-acetylgalactosamine (GalNAc) to serine and threonine residues of target proteins. The UniProt recommended name is Polypeptide N-acetylgalactosaminyltransferase 2 (GALNT2). This enzyme is localized in the Golgi apparatus and is part of a family of glycosyltransferases that regulate protein processing, secretion, and cell signaling.\u003cbr\u003e\u003cbr\u003eFunctionally, GALNT2 antibody identifies a 571-amino-acid type II transmembrane protein with an N-terminal cytoplasmic tail, a single transmembrane helix, and a luminal catalytic domain. GALNT2 controls the first step of O-glycan biosynthesis, generating the Tn antigen precursor used for complex glycan assembly. Its substrate selectivity contributes to tissue-specific glycosylation patterns that affect protein stability, receptor signaling, and extracellular matrix composition. Through this activity, GALNT2 regulates cellular adhesion, immune recognition, and lipid metabolism.\u003cbr\u003e\u003cbr\u003eThe GALNT2 gene is located on chromosome 1q42.13 and is broadly expressed in liver, pancreas, intestine, and epithelial tissues. Genetic studies link GALNT2 variants to plasma lipid levels and susceptibility to metabolic disorders. Reduced GALNT2 expression impairs O-glycosylation of apolipoprotein C-III (ApoC3) and ANGPTL3, leading to altered triglyceride metabolism. Conversely, overexpression influences cell surface receptor function and proteolytic shedding of glycoproteins involved in inflammation and cancer progression.\u003cbr\u003e\u003cbr\u003eIn cellular signaling, GALNT2 participates in the regulation of the epidermal growth factor receptor (EGFR) and insulin receptor pathways. Aberrant O-glycosylation mediated by GALNT2 modifies receptor trafficking and ligand responsiveness. In cancer, dysregulated GALNT2 expression is associated with increased proliferation, migration, and metastasis in hepatocellular carcinoma and breast cancer. Conversely, its reduced expression can impair glycan-mediated cell communication and immune regulation.\u003cbr\u003e\u003cbr\u003eGALNT2 antibody is used for immunohistochemistry, western blotting, and glycoproteomics studies to assess Golgi function, protein maturation, and post-translational modification patterns. The enzyme's activity is crucial for mucin biosynthesis, glycoprotein secretion, and metabolic balance. In metabolic research, GALNT2 serves as a biomarker linking glycosylation to lipid homeostasis and cardiovascular disease risk.\u003cbr\u003e\u003cbr\u003eStructurally, GALNT2 contains a catalytic Gal\/GalNAc-T motif and a C-terminal ricin-like lectin domain that determines substrate specificity. These features allow recognition of unmodified peptide regions and extension of O-linked glycans in a sequential manner.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=GALNT2 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=GALNT2 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=GALNT2 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/GALNT2 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=GALNT2+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047308353901,"sku":"FY12958","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_34afd259-511c-4bba-af26-f4a20d430b79.jpg?v=1782237067","url":"https:\/\/www.ebiohippo.com\/products\/galnt2-antibody-polypeptide-n-acetylgalactosaminyltransferase-2-bha17135860","provider":"BioHippo","version":"1.0","type":"link"}