{"product_id":"galp-antibody-galanin-like-peptide-bha17136136","title":"GALP Antibody \/ Galanin-like peptide","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eGALP Antibody \/ Galanin-like peptide is a anti-GALP Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), ELISA with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e GALP\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eGALP antibody detects Galanin-like peptide, a hypothalamic neuropeptide involved in energy balance, feeding behavior, and reproductive hormone regulation. The UniProt recommended name is Galanin-like peptide (GALP). This neuropeptide acts within the central nervous system to integrate metabolic, thermoregulatory, and neuroendocrine signals, linking energy status to reproductive function and stress adaptation.\u003cbr\u003e\u003cbr\u003eFunctionally, GALP antibody identifies a 60-amino-acid peptide derived from a larger precursor encoded by the GALP gene. The peptide binds to galanin receptors GALR1, GALR2, and GALR3, activating G protein-mediated signaling pathways that influence neuronal excitability and neuroendocrine secretion. GALP is expressed primarily in the arcuate nucleus and median eminence of the hypothalamus, where it regulates appetite, body temperature, and pituitary hormone release. Its expression is modulated by leptin, insulin, and circulating glucose levels, positioning GALP as a metabolic signal integrator.\u003cbr\u003e\u003cbr\u003eThe GALP gene is located on chromosome 19q13.43 and exhibits conserved expression in mammals, reflecting its importance in metabolic control. GALP neurons project to hypothalamic and extrahypothalamic regions involved in feeding and thermoregulation, including the paraventricular nucleus and dorsal raphe.\u003cbr\u003e\u003cbr\u003ePathologically, dysregulation of GALP signaling contributes to metabolic and neuroendocrine disorders such as obesity, infertility, and hypothalamic dysfunction. Reduced GALP expression is associated with leptin deficiency and disrupted reproductive cycling, while elevated levels influence energy expenditure and thermogenesis. Research using GALP antibody supports studies in neuroendocrinology, energy metabolism, and reproductive physiology.\u003cbr\u003e\u003cbr\u003eGALP antibody is validated for immunohistochemistry, immunofluorescence, and ELISA to detect neuropeptides in hypothalamic and pituitary tissues. \u003cbr\u003e\u003cbr\u003eStructurally, Galanin-like peptide shares sequence homology with galanin in its N-terminal region, allowing interaction with the same receptor family but with distinct potency and distribution. Post-translational processing of prepro-GALP yields the mature peptide with amidated C-terminus essential for receptor activation. This antibody enables analysis of GALP's role in central metabolic control and neuroendocrine integration.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=GALP - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=GALP - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=GALP - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/GALP - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=GALP+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047319757165,"sku":"FY13234","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_0e63dad4-628b-4f1b-94aa-4232be0abfd8.jpg?v=1782237101","url":"https:\/\/www.ebiohippo.com\/products\/galp-antibody-galanin-like-peptide-bha17136136","provider":"BioHippo","version":"1.0","type":"link"}